keratoacanthoma

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keratoacanthoma

 [ker″ah-to-ak″an-tho´mah]
a rapidly growing, benign papular lesion, with a superficial crater filled with a keratin plug, usually on the face; it resolves spontaneously.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ker·a·to·ac·an·tho·ma

(ker'ă-tō-ak'an-thō'mă),
A rapidly growing tumor that may be umbilicated, and usually occurs on exposed areas of the skin in elderly white men, which invades the dermis but remains localized and usually resolves spontaneously if untreated; microscopically, the nodule is composed of well-differentiated squamous epithelium with a central keratin mass that opens on the skin surface.
[kerato- + G. akantha, thorn, +-oma, tumor]
Farlex Partner Medical Dictionary © Farlex 2012

keratoacanthoma

Dermatology A benign proliferation of squamous epithelium caused by infundibular hyperplasia and squamous metaplasia of sebaceous glands, which may histologically mimic WD (well differentiated) SCC. Cf Squamous cell carcinoma.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

ker·a·to·ac·an·tho·ma

(ker'ă-tō-ak'an-thō'mă)
A rapidly growing, umbilicated tumor, usually occurring on exposed areas of the skin, which invades the dermis but remains localized and usually resolves spontaneously.
[kerato- + G. akantha, thorn, + -oma, tumor]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

keratoacanthoma

(kĕr″ă-tō-ăk″ăn-thō′mă) [″ + akantha, thorn, + oma, tumor]
Enlarge picture
KERATOACANTHOMA
A common benign tumor that has a mound-shaped body with a central keratin-filled crater. The lesion clinically and histologically resembles squamous cell carcinoma of the skin, and may be related to this cancer. See: illustration

Treatment

Spontaneous healing of the tumor is common. Lesions that do not heal on their own can be surgically excised.

illustration
Medical Dictionary, © 2009 Farlex and Partners

keratoacanthoma

A wart-like growth, usually occurring on the face in elderly people, that rapidly increases in size over the course of two months until it is about a centimetre in diameter, hemispherical and with a central white horny plug. If left alone for a month or two, the keratoacanthoma begins to get smaller and eventually disappears leaving a depressed scar. Doubt as to diagnosis, however, often dictates removal for examination.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

ker·a·to·ac·an·tho·ma

(ker'ă-tō-ak'an-thō'mă)
A rapidly growing, umbilicated tumor, usually occurring on exposed areas of the skin, which invades the dermis but remains localized and usually resolves spontaneously.
[kerato- + G. akantha, thorn, +-oma, tumor]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Escudier et al., "Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib," Journal of Clinical Oncology, vol.
A number of diseases, such as Crohn's diseases, synovitis-acne-pustulosis-hyperostosis-osteitis syndrome, pyoderma gangrenosum, and tumors (SCC, keratoacanthoma, and adenocarcinoma) have been described to coexist with AI.
Cutaneous squamous cell carcinomas (SCC) and keratoacanthomas were identified in 19% of monotherapy patients compared with between 2% and 7% of combination therapy patients.
Value of MLH1 and MSH2 Mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas. J invest Dermatol 2006;126:2302-2307.
Supplementing with essential fatty acids (found in oils such as corn and safflower) may be useful in the case of keratoacanthomas, but again consult your vet as to dosage and frequency of administration.
Also trending in medical dermatology are best practices for intralesional injections of 5-FU to treat the often challenging isomorphic squamous cell carcinomas (SCCs) or keratoacanthomas on the lower leg, as well as use of neoadjuvant hedgehog inhibitors to shrink large skin cancer lesions, according to Glenn David Goldman, MD.
Cutaneous nodules are found in many other disorders, including Gardner syndrome, Cowden syndrome, multiple trichoepitheliomas, (32) basal cell nevus syndrome, (33) multiple keratoacanthomas, (34) and tuberous sclerosis (35) (Table).
Muir-Torre Syndrome: Muir-Torre syndrome (MTS) is defined by the development of internal malignancy, most commonly colon cancer, in association with sebaceous adenomas and epitheliomas, sebaceous carcinomas and multiple or early-onset keratoacanthomas. Sebaceous adenoma is believed to be the most specific lesion of Muir-Torre syndrome.
In the involution stage, up to 50% of keratoacanthomas undergo spontaneous resolution with expulsion of the keratin plug and resorption of the tumoral mass.
Keratoacanthomas (KAs) sometimes occur over scar sites, as did this lesion.