keratoacanthoma

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keratoacanthoma

 [ker″ah-to-ak″an-tho´mah]
a rapidly growing, benign papular lesion, with a superficial crater filled with a keratin plug, usually on the face; it resolves spontaneously.

ker·a·to·ac·an·tho·ma

(ker'ă-tō-ak'an-thō'mă),
A rapidly growing tumor that may be umbilicated, and usually occurs on exposed areas of the skin in elderly white men, which invades the dermis but remains localized and usually resolves spontaneously if untreated; microscopically, the nodule is composed of well-differentiated squamous epithelium with a central keratin mass that opens on the skin surface.
[kerato- + G. akantha, thorn, +-oma, tumor]

keratoacanthoma

/ker·a·to·ac·an·tho·ma/ (ker″ah-to-ak″an-tho´mah) a benign, locally destructive, epithelial tumor closely resembling squamous cell carcinoma, manifested as one or more craters, each filled with a keratin plug and usually resolving spontaneously.

keratoacanthoma

[ker′ətō·ak′anthō′mə] pl. keratoacanthomas, keratoacanthomata
Etymology: Gk, keras + akantha, thorn + oma, tumor
a benign, rapidly growing, flesh-colored papule or nodule of the skin with a central plug of keratin. The lesion is most common on the face or the back of the hands and arms. It disappears spontaneously in 4 to 6 months, leaving a slightly depressed scar. Biopsy is often necessary to differentiate it from a squamous cell carcinoma.
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Keratoacanthoma

keratoacanthoma

Dermatology A benign proliferation of squamous epithelium caused by infundibular hyperplasia and squamous metaplasia of sebaceous glands, which may histologically mimic WD (well differentiated) SCC. Cf Squamous cell carcinoma.

ker·a·to·ac·an·tho·ma

(ker'ă-tō-ak'an-thō'mă)
A rapidly growing, umbilicated tumor, usually occurring on exposed areas of the skin, which invades the dermis but remains localized and usually resolves spontaneously.
[kerato- + G. akantha, thorn, + -oma, tumor]

keratoacanthoma

(kĕr″ă-tō-ăk″ăn-thō′mă) [″ + akantha, thorn, + oma, tumor]
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KERATOACANTHOMA
A common benign tumor that has a mound-shaped body with a central keratin-filled crater. The lesion clinically and histologically resembles squamous cell carcinoma of the skin, and may be related to this cancer. See: illustration

Treatment

Spontaneous healing of the tumor is common. Lesions that do not heal on their own can be surgically excised.

illustration

keratoacanthoma

A wart-like growth, usually occurring on the face in elderly people, that rapidly increases in size over the course of two months until it is about a centimetre in diameter, hemispherical and with a central white horny plug. If left alone for a month or two, the keratoacanthoma begins to get smaller and eventually disappears leaving a depressed scar. Doubt as to diagnosis, however, often dictates removal for examination.

keratoacanthoma

rapid-growing, localized skin tumour; i.e. central mass of skin surface keratin which invades the dermis; undergoes spontaneous resolution

ker·a·to·ac·an·tho·ma

(ker'ă-tō-ak'an-thō'mă)
A rapidly growing, umbilicated tumor, usually occurring on exposed areas of the skin, which invades the dermis but remains localized and usually resolves spontaneously.
[kerato- + G. akantha, thorn, +-oma, tumor]

keratoacanthoma (ker´ətōak´an-thō´mə),

n (“self-healing carcinoma”) a rapidly growing papular lesion with a superficial crater filled with keratin. Clinical and histopathologic features of this lesion are very similar to well-differentiated squamous cell carcinoma; however, most consider this growth to be benign. Treatment is conservative excision.
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Keratoacanthoma.

keratoacanthoma

see intracutaneous cornifying epithelioma.
References in periodicals archive ?
Multiple keratoacanthoma in discoid lupus erythematosus.
Intraepidermal elastic fibers and intracytoplasmic glycogen: diagnostic aids in differentiating keratoacanthoma from squamous cell carcinoma.
Traumatic keratoacanthoma arising in a 15-year-old boy following a motor vehicle accident.
Pattee SF, Silvis NG, Keratoacanthoma developing in sites of previous trauma: a report of two cases and review of the literature.
Topical treatment with imiquimod may induce regression of facial keratoacanthoma Eur J Dermatol 2003;13:80-82.
MUILTIPLE GIANT KERATOACANTHOMAS TREATED WITH SUBCUTANEOUS INTERFERON [alpha]-2A AND ORAL ISOTRETINOIN.
Abstract #8520 : "Presence of frequent underlying RAS mutations in cutaneous squamous cell carcinomas and keratoacanthomas (cuSCC/KA) that develop in patients during vemurafenib therapy.