keratoacanthoma


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Related to keratoacanthoma: squamous cell carcinoma
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keratoacanthoma

 [ker″ah-to-ak″an-tho´mah]
a rapidly growing, benign papular lesion, with a superficial crater filled with a keratin plug, usually on the face; it resolves spontaneously.

ker·a·to·ac·an·tho·ma

(ker'ă-tō-ak'an-thō'mă),
A rapidly growing tumor that may be umbilicated, and usually occurs on exposed areas of the skin in elderly white men, which invades the dermis but remains localized and usually resolves spontaneously if untreated; microscopically, the nodule is composed of well-differentiated squamous epithelium with a central keratin mass that opens on the skin surface.
[kerato- + G. akantha, thorn, +-oma, tumor]

keratoacanthoma

Dermatology A benign proliferation of squamous epithelium caused by infundibular hyperplasia and squamous metaplasia of sebaceous glands, which may histologically mimic WD (well differentiated) SCC. Cf Squamous cell carcinoma.

ker·a·to·ac·an·tho·ma

(ker'ă-tō-ak'an-thō'mă)
A rapidly growing, umbilicated tumor, usually occurring on exposed areas of the skin, which invades the dermis but remains localized and usually resolves spontaneously.
[kerato- + G. akantha, thorn, + -oma, tumor]

keratoacanthoma

(kĕr″ă-tō-ăk″ăn-thō′mă) [″ + akantha, thorn, + oma, tumor]
Enlarge picture
KERATOACANTHOMA
A common benign tumor that has a mound-shaped body with a central keratin-filled crater. The lesion clinically and histologically resembles squamous cell carcinoma of the skin, and may be related to this cancer. See: illustration

Treatment

Spontaneous healing of the tumor is common. Lesions that do not heal on their own can be surgically excised.

illustration

keratoacanthoma

A wart-like growth, usually occurring on the face in elderly people, that rapidly increases in size over the course of two months until it is about a centimetre in diameter, hemispherical and with a central white horny plug. If left alone for a month or two, the keratoacanthoma begins to get smaller and eventually disappears leaving a depressed scar. Doubt as to diagnosis, however, often dictates removal for examination.

ker·a·to·ac·an·tho·ma

(ker'ă-tō-ak'an-thō'mă)
A rapidly growing, umbilicated tumor, usually occurring on exposed areas of the skin, which invades the dermis but remains localized and usually resolves spontaneously.
[kerato- + G. akantha, thorn, +-oma, tumor]
References in periodicals archive ?
Histology is the gold standard in diagnosing a keratoacanthoma. A deep biopsy specimen that preferably includes part or full subcutaneous fat with excision of the entire lesion should allow for good histologic interpretation and diagnosis.
Sorafenib, a multikinase inhibitor (including VEGF receptors), has been associated with actinic keratosis, focal squamous atypia, keratoacanthoma, and squamous cell carcinoma [23-25].
Dowling-Degos disease, hidradenitis suppurativa, and multiple keratoacanthomas. A disorder that may be caused by a single underlying defect in pilosebaceous epithelial proliferation.
The histological changes without the visualization of the organism may prompt an erroneous diagnosis of squamous cell carcinoma or keratoacanthoma. (6) Oral antifungal agents, i.e.
Verrucous cell carcinoma arising from an underlying giant keratoacanthoma. International Journal of Lower Extremity Wounds 2012; 11 (2).
A giant MC is a rare nodular variant of MC with a diameter of more than 0.5-1cm.1,2 The giant variant can be a single lesion localising on the eyelid, scalp, or sole, and can easily be confused with basal cell carcinoma, verruca vulgaris, comedone, abscess, furuncle, condylome, keratoacanthoma, and various adenomas.6,8 The eyelid involvement of MC can cause chronic conjunctivitis.2 Giant MC lesions are rarely seen in healthy individuals and are usually reported in patients with HIV and those on immunosuppressive diseases.2,3
Cutaneous metastases from carcinoma of lung mimicking a keratoacanthoma
Examination of skin lesions ranging from keratoacanthoma to a grade IV spindle cell carcinoma revealed very strong p63 immunoreactivity in grade 3 SCC with decrease in a single grade IV spindle SCC.
Other forms of squamous cell carcinoma include keratoacanthoma, actinic chelitis, and Bowen's disease.
Their study identified seven cases of cutaneous SCC and two cases of SCC keratoacanthoma, including two cases of focal squamous atypia and three cases of actinic keratosis, with a mean time to development of 9.3 months.
The following histopathologic diagnoses were included: malignant melanoma, basal-cell carcinoma, squamous-cell carcinoma, keratoacanthoma, Merkel-cell carcinoma, apocrine carcinoma and variants, eccrine carcinoma and variants, sebaceous carcinoma, and trichocarcinoma and variants.
Squamous cell carcinoma (SCC) or avian keratoacanthoma is a neoplastic skin lesion of unknown etiology that has been well described in birds.