Apart from these three, three more entities which are filled with keratinous debris can occur in the body, namely, teratoma, keratinous cyst
, and trichilemmal cyst.
Characteristically many thin-walled small blood vessels with frequent neutrophils infiltrate and entrapped epithelial component in 20-30% of cases as Keratinous cyst
, Thin strands of squamous epithelium and Basaloid buds.
Key Words: Chalazion, curettage, keratinous cyst
, tatsal plate, tumor
Microscopy: Keratinous debritic material along with a nucleate squamous s/o Keratinous cyst
Our female patient also exhibited numerous milia, benign keratinous cysts
that commonly present periorbitally.
Occasional keratinous cysts
and a matrix of varying composition can also be found.7
They proposed the following five histological criteria for diagnosis: 1) nests of cuboidal or polygonal cells; 2) intercommunicating tubuloalveolar structures lined with two or more rows of cuboidal cells; 3) ductal structures composed of one or two rows of cuboidal cells; 4) occasional keratinous cysts
; 5) a matrix of varying composition.
Others suggest that it may originate from chronic abscess or keratinous cysts
Histologically, the tumors contain varying amounts of: nests of cuboidal/polygonal cells, tubuloalveolar structures, ductal structures, keratinous cysts
and matrix (chondroid substance is the most prevalent).
James Jauchem wrote in the Journal of Clinical Epidemiology of "Calamity on Meadow Street" that "in addition to brain tumors, Brodeur seemed to blame exposure to EMF for the following ailments: Osgood Schlatter syndrome [a disease affecting the tendons of the kneecaps], ganglion and keratinous cysts
[small pockets of fluid resulting from inflammation], scoliosis and other spinal deformities, parotid gland inflammation, hypospadias [an abnormality of the penis in which the urethra opens underneath], heart defects, lipodystrophy [a fatty tissue disease], glomerulonephritis [a kidney disorder], strep throat, fever, dark brown urine, pain and swelling in the eyes, swelling of the face, arm numbness, severe headaches, and keratoacanthoma [a disease of the eyes]."
They proposed the following microscopic diagnostic criteria: (a) Nests of cuboidal or polygonal cells; (b) Intercommunicating tubuloalveolar structures lined with two or more rows of cuboidal cells; (c) Ductal structures composed of one or two rows of cuboidal cells; (d) Occasional keratinous cysts
; (e) A matrix of varying composition in hematoxylin and eosin stain.
In 1954, Damste and prakken (1) followed by lowenthal and Prakken in 1961 (2, 4) used the terminology for patients with atrichia with multiple follicular keratinous cysts
. Ahammed et al 1998, who referred this disease as congenital atrichia reported the identification of missense mutation in zinc finger domain of hairless gene that maps on chromosome 8p12 and is implicated in the pathogenesis of APL (5).