When patients were on a calcineurin inhibitor, the risk of keratinocyte
carcinomas increased incrementally by 2.6 events per 100 patients per year of follow-up, and the SCC risk increased by 1.7 events per 100 patients per year of follow-up.
To this end, a bi-channel device has been used to culture the keratinocyte
cell line HaCaT, as a model of the epidermis barrier, on one side, and a human leukemic monocyte lymphoma cell line (U937), to represent human dendritic cells, on the other side (Ramadan and Ting, 2016).
During wound healing process, dermis fibroblasts are responsible for synthesis and deposition of extracellular matrix collagen (Karimi et al., 2013; Dobosz et al., 2014) Keratinocytes
strongly contribute to the modulation of dermal fibroblast collagen production and degradation.
Microrna-31 promotes skin wound healing by enhancing keratinocyte
proliferation and migration.
STAT3 small interfering RNA carried by Lipofectamine 3000 combined with ultrasonic irradiation and SonoVue microbubbles inhibited the growth of psoriatic keratinocytes
In pemphigus vulgaris, there is binding of autoreactive IgG to desmosomal proteins (desmogleins) causing the loss of keratinocyte
Abbreviations CCL: C-C motif chemokine ligand CXCL: C-X-C motif chemokine ligand CX3CL: C-X3-C motif chemokine ligand G-CSF: Granulocyte-colony stimulating factor GM-CSF: Granulocyte-macrophage colony-stimulating factor IFN: Interferon IL: Interleukin K: Keratin KC: Keratinocyte
MMP-9: Matrix metalloproteinase-9 TGFa: Transforming growth factor alpha TNF[alpha]: Tumor necrosis factor alpha TNF[beta] Tumor necrosis factor beta VEGF: Vascular endothelial growth factor.
Recent studies demonstrated that EGF stimulates keratinocyte
division in vitro and epidermal regeneration in vivo .
Regulation of Keratinocyte
terminal differentiation by integrin extracellular matrix interactions.
The Inhibitory Effects of Wnt-CM on Keratinocyte
Migration Are Mediated by c-Myc.
As ROS have been demonstrated to activate many intracellular molecules and upregulate oxidative stress-related genes during wound healing, we hypothesized that ROS might modulate the production of [PGE.sub.2] through MAPKs pathway on mechanical damaged human keratinocytes
, and the increased [PGE.sub.2] might then be responsible for cell injury and repair and inflammatory cell recruitment.
RT-7 cells, an immortalized human keratinocyte
cell line kindly provided by Dr.