keratinocyte


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Related to keratinocyte: melanocyte, Keratinocyte Growth Factor

keratinocyte

 [kĕ-rat´ĭ-no-sīt″]
the cell of the epidermis that synthesizes keratin, known in its successive stages in the various layers of the skin as basal cell, prickle cell, and granular cell.

ke·rat·i·no·cyte

(ke-rat'i-nō-sīt),
A cell of the living epidermis and certain oral epithelium that produces keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum.

keratinocyte

/ke·rat·i·no·cyte/ (ker-at´in-o-sīt) the epidermal cell that synthesizes keratin, known in its successive stages in the layers of the skin as basal cell, prickle cell, and granular cell.

keratinocyte

(kə-răt′n-ə-sīt′, kĕr′ə-tĭn′ə-)
n.
An epidermal cell that produces keratin.

keratinocyte

[kerat′inōsīt′]
Etymology: Gk, keras + kytos, cell
an epidermal cell that synthesizes keratin and other proteins and sterols. These cells constitute 95% of the epidermis, being formed from undifferentiated, or basal, cells at the dermal-epidermal junction. Its characteristic intermediate filament protein is cytokeratin. In its various successive stages, keratin forms the prickle cell layer and the granular cell layer, in which the cells become flattened and slowly die to form the final layer, the stratum corneum, which gradually exfoliates.

ke·rat·i·no·cyte

(kĕ-rat'i-nō-sīt)
A cell of the living epidermis and certain oral epithelium that produces keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum.

keratinocyte

the cell of the epidermis that synthesizes keratin, known in its successive stages in the various layers of the skin as basal cell, prickle cell and granular cell.

keratinocyte transit time
the time required for a keratinocyte to move from its origin in the actively dividing cells of the stratum basale to the surface of the epidermis where it is shed. Called also epidermal renewal time. In the normal dog, this is approximately 22 days.
References in periodicals archive ?
Like aging keratinocytes, old fibroblasts lose energy and responsiveness to growth factors and other cellular signals.
Regulation of Keratinocyte terminal differentiation by integrin extracellular matrix interactions.
It also reduces keratinocyte proliferation in psoriasis.
Human primary keratinocytes were isolated as described by Barlow and Pye [sup][19] and cultured in serum-free defined keratinocyte-serum free medium (SFM) (Gibco Invitrogen Corporation, USA) containing a LC concentration (0.
p63 identifies keratinocyte stem cells," Proceedings of the National Academy of Sciences of the United States of America, vol.
Hanns Hatt, author of the paper and professor of Cellphysiology at Ruhr-Universitat Bochum, the university that collaborated with the Deramatology Department at the University of Munster for the research, said that this resulted to a rise in the proliferation and a quicker migration of keratinocytes - processes which facilitate wound healing.
Based on this finding, the researchers concluded that UV nail lamps do not play a substantial role in the risk of developing keratinocyte carcinoma.
Sodium alginate (medium viscosity) and keratinocyte growth factor were from Sigma Chemical Co.
Retinoid-responsive transcriptional changes in epidermal keratinocytes
The high risk strains such as HPV 16 and 18 begin a transcriptional cascade after cell invasion occurs, and as the host keratinocyte begins to divide and become increasingly differentiated in the upper layers of the epithelium, this is known as cervical intraepithelial lesions and can be detected with a PAP smear.
9) The expression of iNOS and the production of NO have been demonstrated in keratinocyte cultures exposed to serum of pemphigus patients and have been associated with the induction of apoptosis in these cells.