KRT18

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KRT18

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein. Together with its filament partner keratin 8, they are the most commonly expressed of all intermediate filaments, and found in tissues lined by single layer epithelia.
 
Molecular pathology
KRT18 mutations are associated with cryptogenic cirrhosis.
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References in periodicals archive ?
In a clinical trial, HMGB1 represents the circulating indicator of necrosis during acetaminophen hepatotoxicity; full-length and caspase-cleaved keratin-18 are circulating markers of necrosis and apoptosis; hyperacetylated HMGB1 is a serum indicator of pyroptosis and immune cell activation [22, 23].