KRT16

(redirected from keratin-16)

KRT16

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein that provides the structural integrity of epithelial cells. KRT16 may be co-expressed with KRT14 in the oesophagus, tongue and hair follicles.

Molecular pathology
KRT16 mutations are associated with pachyonychia congenita type 1, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
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An underlying disorder of keratinization resulting in hyperproliferation also has been suggested given reports of familial CARP and electron microscopy studies demonstrating focal-enhanced expression of keratin-16 in the stratum granulosom.