keratin filaments

ker·a·tin fil·a·ments

a class of intermediate filaments that form a network within epithelial cells and anchor to desmosomes, thus imparting tensile strength to the tissue.
See also: tonofilament.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Meanwhile, European researchers identified KLHL24 mutations in families from Finland, Germany, Israel, Italy, Switzerland, and Qatar and confirmed that these mutations affect the equilibrium between intermediate keratin filaments and keratin breakdown that is necessary for skin integrity (Am J Hum Genet.
They contain keratin filaments, filaggrin (protein surrounding keratin filaments) and the natural moisturizing factor (NMF), elements that confer flexibility and mechanical resilience to the SC.
In BDD, cows develop lesions with long keratin filaments in skin just above the hooves.
(2) An important aspect of stratified squamous epithelia is that the cells undergo a terminal differentiation program that results in the formation of a mechanically resistant and toughened surface composed of cornified cells that are filled with keratin filaments and lack nuclei and cytoplasmic organelles.
Filaggrin proteins cause keratin filaments in the epidermis to aggregate in ways that prevent epidermal water loss and impede entry of unwanted environmental chemicals, haptens, and proteins.
Keratosis usually features a total replacement of superficial epithelial cells by keratin filaments and by dissolution of the nuclei.
Also known as filament aggregating protein, filaggrin consolidates keratin filaments into dense bundles in the granular layer of the epidermis during the terminal phase of epithelial differentiation, forming a tight matrix that also maintains moisture within the skin, he explained.
The mutation might have impaired the liver's ability to reorganize keratin filaments in response to physiologic stress.
GREEN: What are the differences in mechanical properties between keratin filaments and type III filaments?
The researchers thought this protein linked the intricate network of keratin filaments inside each skin cell to certain molecules in the cell membrane.
Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16.
We have calculated what this means in terms of the extent of cross-linking of keratin filaments. Assuming that keratin filaments are 15 nm wide, and assuming a model in which the filaments completely line the intracellular surface of the cell envelope, we calculate about one crosslink per 100 nm of filament length.

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