keratan sulfate


Also found in: Acronyms, Wikipedia.

keratan sulfate

 [ker´ah-tan]
either of two sulfated mucopolysaccharides (I and II). Keratan sulfate is an important component of the proteoglycan of cartilage, and occurs in the cornea and the nucleus pulposus, and is also an accumulation product in Morquio's syndrome.

ker·a·tan sul·fate

(ker'ă-tan sŭl'fāt),
A type of sulfated mucopolysaccharide containing d-galactose in place of the uronic acid of hyaluronic acid or chondroitin; also containing unsulfated and 6-sulfated N-acetyl-d-glucosamine; found in cartilage, bone, connective tissue, the cornea, aorta, and in the intervertebral disks; accumulates in Morquio syndrome; keratan sulfate I is abundant in cornea and is attached to a protein via an asparaginyl residue; keratan sulfate II is found in loose connective tissue and bone and is linked to a seryl or threonyl residue.
Synonym(s): keratosulfate

keratan sulfate

/ker·a·tan sul·fate/ (ker´ah-tan) either of two glycosaminoglycans (I and II), consisting of repeating disaccharide units of N -acetylglucosamine and galactose, but differing slightly in carbohydrate content and localization. It occurs in cartilage, the cornea, and in the nucleus pulposus and is also an accumulation product in Morquio's syndrome.

keratan sulfate

(kĕr′ə-tăn′)
n.
Any of several glycosaminoglycans found especially in the cornea, cartilage, and bone.

ker·a·tan sul·fate

(ker'ă-tan sŭl'fāt)
A type of sulfated mucopolysaccharide found in cartilage, bone, connective tissue, the cornea, aortae, and in the intervertebral discs; accumulates in Morquio syndrome.
Synonym(s): keratosulfate.

keratan sulfate

a glycosaminoglycan which exists as either of two sulfated mucopolysaccharides (I and II). Keratan sulfate is an important component of the proteoglycan of cartilage, and occurs in the cornea and the nucleus pulposus.
References in periodicals archive ?
Recently, the use of an immune-based assay for the quantification of keratan sulfate in MPS IVA has been reported (49).
Development and testing of new screening method for keratan sulfate in mucopolysaccharidosis IVA.
Identification of a common mutation in mucopolysaccharidosis IVA: correlation among genotype, phenotype, and keratan sulfate.
M3] Heparan sulfate MPS I, MPS IIIA, MPS IIIB, MPS VII Keratan sulfate MPS IVA 49 Trihexosylceramide Fabry References Marker Immune Histology capture (activity) Protein [alpha]-L-Iduronidase 37, 60 Iduronate-2-sulfatase 61 Sulfamidase N-Acetyl-galactosamine- 38, 43, 72, 73 4-sulfatase [alpha]-Galactosidase 41 Saposin C Saposin C Acid [alpha]-glucosidase 59 [beta]-Glucosidase 44 LAMP-1 LAMP-2 CCL18 Chitotriosidase (a) Substrate [G.
The biosynthesis of GAG structures differs from the "small O-linked glycans" in 2 significant ways: (a) the transferases required are all specific and not involved in other glycoconjugate classes, with the exception of chondroitin 6-sulfotransferase, keratan sulfate Gal-6-sulfotransferase, and the GlcNAc 6-O-sulfotransferase that also sulfates N-acetyllactosamine extensions (60); and (b) the mechanism of GAG chain elongation is different.
MCD is characterized by nonsulfated (MCD type I) or low-sulfated (MCD type II) keratan sulfate (104).
Keratan sulfate in serum and cartilage is nonsulfated or low-sulfated (107, 108).
Currently, MCD can be diagnosed with an ELISA that makes use of a monoclonal antibody specific for a sulfated epitope on keratan sulfate (110).
These disorders all store either heparan sulfate, dermatan sulfate, keratan sulfate, or a combination of these.