Nuclear alterations (anisokaryosis, anisocytosis, and karyomegaly
) were described.
Within one section of kidney, very rare tubular epithelial cells of the medullary cone displayed karyomegaly
with large, 13-[micro]m, glassy, basophilic, intranuclear, viral inclusion bodies.
25 He observed karyomegaly
in the PCTs of the frog which was most marked in the 10-day treatment group.
Binucleated and multinucleated cells as well as karyomegaly
were multifocally observed.
In the four high-grade tumors with a low mitotic index, karyomegaly
(n=3) (Figure 1b), bizarre nuclei (n=1) and multinucleated cells (n=1) were seen.
These findings were correlated with the amelioration of CSP-induced tubular necrosis, degeneration, karyomegaly
, and tubular dilatation .
The bizzare nuclei or 2-fold karyomegaly
was absent in this study.
The bone marrow also showed similar cells, with karyomegaly
, dense chromatin, and coalescing vacuoles which were Periodic Acid Schiff (PAS) negative.
was zonal, being prominent near the central veins.