kappa light chain

kappa light chain

one of two kinds of smaller peptide chains present in an immunoglobulin molecule. See also lambda light chain.
References in periodicals archive ?
9 g/dL, increased serum IgM level of 2340 mg/L (normal range: 56-352 mg/dL), free kappa light chain level of 7.
KA upregulated and UR down-regulated the expressions of nuclear factor of kappa light chain (Nfkbia) gene and IL-1[beta] gene, which are associated with inflammation.
Bone marrow aspirate showed 8% to 10% plasma cells, and bone marrow biopsy showed 15% plasma cells with kappa light chain restriction.
Crystal-storing histiocytosis: a disorder occurring in plasmacytic tumors expressing immunoglobulin kappa light chain.
The VelocImmune mice contain the full repertoire of human heavy chain immunoglobulin genes and kappa light chain genes, each linked to endogenous mouse constant regions.
Crescendo has already made use of its ability to knock out lambda light chain to generate proprietary 'triple knockout' mice that have the immunoglobulin heavy chain, kappa light chain and lambda light chain loci all functionally deleted.
In a study including juvenile idiopathic arthtiris (JIA) patients, abnormalities in the peripheral B cell pool, namely kappa light chain repertoire were observed and the possibility of disturbance in B cell tolerance by multiple pathogenic mechanisms in JIA was highlighted.
Sensitive probes include: Epstein-Barr encoded RNA (EBER), kappa light chain, lambda light chain, dual kappa/lambda, IgA-alpha heavy chain, IgG-gamma heavy chain, IgM-mu heavy chain, and ribosomal RNA (positive control).
KappaSelect is designed for the purification of antibodies and antibody fragments containing the kappa light chain.
Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis.
Further laboratory results revealed that the patient had an elevated serum free kappa light chain at 1080 mg/dL with a kappa/ lambda ratio of 800.