kaolin clotting time

kaolin clotting time (KCT),

a sensitive test of platelet-poor plasma for detecting lupus anticoagulants in mixtures of plasma taken from patients and from control groups; kaolin initiates clotting through the contact factors and subsequently involves other factors in the intrinsic pathway of coagulation.

ka·o·lin clot·ting time

(KCT) (kā'ō-lin klot'ing tīm)
A sensitive test of platelet-poor plasma for detecting lupus anticoagulants in mixtures of plasmas taken from patients and from control groups; kaolin initiates clotting through the contact factors and subsequently involves the other factors in the intrinsic pathway of coagulation.
Mentioned in ?
References in periodicals archive ?
The effect is more pronounced with reagents whose phospholipid content is relatively low (12) and may be greater with the kaolin clotting time (KCT) than with the dilute Russell viper venom test (dRVVT) (14).
Kaolin clotting time and dilute Russell viper venom time distinguish between prothromb-independent and beta 2-glycoprotein I-dependent anti phospholipid antibodies.
[1] Nonstandard abbreviations: LA, lupus anticoagulant; [beta]2-GPI, [beta]2-glycoprotein I; KCT, kaolin clotting time; dRVVT, dilute Russell viper venom test; SCT, silica clotting time; APTT, activated partial thromboplastin time; ICA, index of circulating anticoagulant.
ABBREVIATIONS: APL = antiphospholipid antibodies; APS = antiphospholipid syndrome; APTT = activated partial thromboplastin time; [[beta].sub.2]-GPI = [beta.sub.2]-glycoprotein I; dRVVT = dilute Russell's viper venom time; ELISA = enzyme-linked immunosorbent assay; Ig = immunoglobulin; KCT = kaolin clotting time; LA = lupus anticoagulant.
Instead, use the kaolin clotting time or other tests with increased sensitivity to the presence of the factor inhibiting phospholipid-dependent reactions in the clotting test, Dr.
At present, the most used screening tests for detecting LA are a dilute activated partial thromboplastin time, kaolin clotting time, and the diluted Russell venom time.
As compared to kaolin clotting time, silica clotting time is a specific and sensitive automated method for detecting lupus anticoagulant.
The LA activity of the isolated IgG was tested with the dilute Russell viper venom test (dRVVT; American Diagnostica Inc.) and an in-house kaolin clotting time (KCT), performed with a 20 g/L kaolin suspension in water.
[3] Nonstandard abbreviations: LA, lupus anticoagulant; [[beta].sub.2]-GPI, [[beta].sub.2]-glycoprotein I; dRVVT, dilute Russell viper venom test; KCT, kaolin clotting time; ICA, index of circulating anticoagulant; and aPTT, activated partial thromboplastin time.
Among the phospholipid-dependent tests, APTT, kaolin clotting time (KCT), diluted Russell viper venom test (dRVVT), and diluted prothrombin time are the tests used most frequently to detect LA (11).
Kaolin clotting time and dilute Russell's viper venom time distinguish between prothrombin-dependent and R2-glycoprotein I-dependent anti phospholipid antibodies.