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The effect is more pronounced with reagents whose phospholipid content is relatively low (12) and may be greater with the kaolin clotting time (KCT) than with the dilute Russell viper venom test (dRVVT) (14).
Kaolin clotting time and dilute Russell viper venom time distinguish between prothromb-independent and beta 2-glycoprotein I-dependent anti phospholipid antibodies.
It is recommended that LA be initially screened using tests such as modified activated partial thromboplastin time (APTT), kaolin clotting time (KCT), and dilute Russell's viper venom time (dRVVT).
Instead, use the kaolin clotting time or other tests with increased sensitivity to the presence of the factor inhibiting phospholipid-dependent reactions in the clotting test, Dr.
Silica clotting time (SCT) has been described as a specific and sensitive alternative to kaolin clotting time for detecting LA (6-9).