SERPINA4

(redirected from kallistatin)

SERPINA4

A gene on chromosome 14q31-q32.1 that encodes a member of the serine protease inhibitor (serpin) family that inhibits amidolytic and kininogenase activities of tissue kallikrein.
References in periodicals archive ?
Huang et al., "Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis," Scientific Reports, vol.
Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury
Chao, "Role of Kallistatin treatment in aging and cancer by modulating miR-34a and miR21 expression," Oxidative Medicine and Cellular Longevity, vol.
miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells
reveal novel mechanisms of kallistatin in protection against senescence, aging, and cancer by modulating miR-34a and miR-21 levels and inhibiting oxidative stress.
MicroRNA Regulation of Oxidative Stress
Plasma kallistatin levels in patients with severe community-acquired pneumonia.
Can serum surfactant protein d levels be used as an effective factor instead of clinical severity scores of pneumonia in pediatric emergency departments?
Cellular localization of kallistatin and tissue kallikrein in human pancreas and salivary glands.
Distribution of 15 human kallikreins in tissues and biological fluids
Kallistatin was first identified in human plasma as a tissue kallikrein inhibitor and a serine proteinase inhibitor [20-23].
Kallistatin Inhibits Oxidative Stress and Inflammation
Reduced kallistatin levels are correlated with increased oxidative stress, inflammation, and organ damage in animal models of hypertension, cardiovascular, and renal damage [22, 35, 40, 42].
Kallistatin is an antioxidant as its heparin-binding site is essential for blocking TNF-[alpha]-induced NADPH oxidase activity and expression in endothelial cells [33, 42].
Role of Kallistatin Treatment in Aging and Cancer by Modulating miR-34a and miR-21 Expression
Kallistatin was first identified in human plasma as a tissue kallikrein-binding protein (KBP) and characterized as a serine proteinase inhibitor (serpin) [1-3].
Kallistatin belongs to the serpin family, which includes a1-antitrypsin and a1-antichymotrypsin [2].
Reduced Circulating Kallistatin Levels Are Inversely Associated with Oxidative Stress
Opposing Effects of Oxygen Regulation on Kallistatin Expression: Kallistatin as a Novel Mediator of Oxygen-Induced HIF-1-eNOS-NO Pathway
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