SERPINA4

(redirected from kallistatin)

SERPINA4

A gene on chromosome 14q31-q32.1 that encodes a member of the serine protease inhibitor (serpin) family that inhibits amidolytic and kininogenase activities of tissue kallikrein.
References in periodicals archive ?
Huang et al., "Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis," Scientific Reports, vol.
Chao, "Role of Kallistatin treatment in aging and cancer by modulating miR-34a and miR21 expression," Oxidative Medicine and Cellular Longevity, vol.
reveal novel mechanisms of kallistatin in protection against senescence, aging, and cancer by modulating miR-34a and miR-21 levels and inhibiting oxidative stress.
Cellular localization of kallistatin and tissue kallikrein in human pancreas and salivary glands.
Kallistatin was first identified in human plasma as a tissue kallikrein inhibitor and a serine proteinase inhibitor [20-23].
Kallistatin Inhibits Oxidative Stress and Inflammation
Reduced kallistatin levels are correlated with increased oxidative stress, inflammation, and organ damage in animal models of hypertension, cardiovascular, and renal damage [22, 35, 40, 42].
Kallistatin is an antioxidant as its heparin-binding site is essential for blocking TNF-[alpha]-induced NADPH oxidase activity and expression in endothelial cells [33, 42].
Kallistatin was first identified in human plasma as a tissue kallikrein-binding protein (KBP) and characterized as a serine proteinase inhibitor (serpin) [1-3].
Kallistatin belongs to the serpin family, which includes a1-antitrypsin and a1-antichymotrypsin [2].
Reduced Circulating Kallistatin Levels Are Inversely Associated with Oxidative Stress