KLK6

(redirected from kallikrein-related peptidase 6)

KLK6

A gene on chromosome 19q13.3 that encodes a serine protease that catalyses amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins (such as fibronectin, laminin, vitronectin and collagen). It may be involved in regulating axon outgrowth following spinal cord injury. KLK6 may play a role in invasion and metastasis.

Molecular pathology
KLK6 degrades alpha-synuclein, preventing its polymerisation, suggesting a role in the pathogenesis of Parkinson disease and other synucleinopathies.
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References in periodicals archive ?
Kotzsch et al., "Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients," Biological Chemistry, vol.
Yoon et al., "Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer," Tumor Biology, vol.
Serge et al., "High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis," Journal of Cellular and Molecular Medicine, vol.
KLK6, the protein encoded by the Kallikrein-related peptidase 6 (KLK6) [5] gene, is a promising biomarker that is frequently overexpressed at the mRNA and protein levels in tissues and fluids derived from patients with ovarian cancer (OCa) and implicated in a variety of normal physiological processes (3).
The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6).
[6] Human genes: KLK8, kallikrein-related peptidase 8; KLK3, kallikrein-related peptidase 3; KLK5, kallikrein-related peptidase 5; KLK6, kallikrein-related peptidase 6; KLK7, kallikrein-related peptidase 7; KLK10, kallikrein-related peptidase 10; KLK11, kallikrein-related peptidase 11; KLK13, kallikrein-related peptidase 13; KLK14, kallikrein-related peptidase 14; ERBB4, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); LOX, lysyl oxidase.