KLK2

(redirected from kallikrein-related peptidase 2)

KLK2

A gene on chromosome 19q13.33 that encodes a serine protease with diverse physiological functions, which may also have a role in carcinogenesis. KLK2 is highly expressed in prostate cancer and may serve as a prognostic marker for prostate cancer.
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References in periodicals archive ?
Prostate-specific antigen (PSA) [10] and a closely related protease, kallikrein-related peptidase 2 (hK2), are commonly used as markers of prostate cancer (1, 2).
The risk of prostate cancer has been associated with single-nucleotide polymorphisms (SNPs) located in the genes coding for PSA (KLK3, kallikrein-related peptidase 3) (19-24) and hK2 (KLK2, kallikrein-related peptidase 2) (25-29).
[10] Nonstandard abbreviations: PSA, prostate-specific antigen; hK2, kallikrein-related peptidase 2; fPSA, free PSA; cPSA, complexed PSA; tPSA, total PSA; SNP, single nucleotide polymorphism; Mab, monoclonal antibody; LD, linkage disequilibrium; MAF, minor allele frequency.
[8] Human genes: KLK3, kallikrein-related peptidase 3; TERT, telomerase reverse transcriptase; FGFR2, fibroblast growth factor receptor 2; TBBX3, T-box protein 3; KLK15, kallikrein-related peptidase 15; KLK2, kallikrein-related peptidase 2; KLK1, kallikrein-related peptidase 1; ACPT, acid phosphatase, testicular; GPR32, G protein-coupled receptor 32; INS, insulin; KLK4, kallikrein-related peptidase 4; KLK9, kallikrein-related peptidase 9; KLK10, kallikrein-related peptidase 10; KLK14, kallikrein-related peptidase 14.
[4] Human genes: AR, androgen receptor; PIK3CA, phosphoinositide-3-kinase, catalytic, alpha polypeptide; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; BRAF, v-raf murine sarcoma viral oncogene homolog B1; KLK3, kallikrein-related peptidase 3; KLK2, kallikrein-related peptidase 2.