KLK15

(redirected from kallikrein-related peptidase 15)

KLK15

A gene on chromosome 19q13.3-q13.4 that encodes a serine  endopeptidase with a trypsin- and chymotrypsin-like substrate specificity, which may: activate/inactivate proteinase-activated receptors F2R, F2RL1 and F2RL3, as well as other kallikreins (e.g., KLK1, KLK3, KLK5 and KLK11); liquefy seminal clot by cleaving semenogelins SEMG1 and SEMG2 and activating KLK3; cleave desmoglein DSG1, resulting in shedding of superficial keratinocytes from the skin surface; and play a role in tumour progression by affecting growth, invasion and angiogenesis.
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References in periodicals archive ?
KLK15 (kallikrein-related peptidase 15), a cancer-related serine protease gene belonging to the same gene family as PSA (40),is identified among the most probable predicted targets of miR-224 (31, 36).
[4] Human genes: MIR, microRNA gene family; API5, apoptosis inhibitor 5; AP2M1, adaptor-related protein complex 2, mu 1 subunit; CDC42, cell division cycle 42 (GTP binding protein, 25 kDa); CXCR4, chemokine (C-X-C motif) receptor 4; SMAD4, SMAD family member 4; SMAD5, SMAD family member 5; SLMAP, sarcolemma-associated protein; H3.3B, H3 histone, family 3B (H3.3B); DIO1, deiodinase, iodothyronine, type I; VHL, von Hippel--Lindau tumor suppressor, E3 ubiquitin protein ligase; HIF1A, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); KLK10, kallikrein-related peptidase 10; KLK1, kallikrein 1; KLK15, kallikrein-related peptidase 15.