KLK15

(redirected from kallikrein-like serine protease)

KLK15

A gene on chromosome 19q13.3-q13.4 that encodes a serine  endopeptidase with a trypsin- and chymotrypsin-like substrate specificity, which may: activate/inactivate proteinase-activated receptors F2R, F2RL1 and F2RL3, as well as other kallikreins (e.g., KLK1, KLK3, KLK5 and KLK11); liquefy seminal clot by cleaving semenogelins SEMG1 and SEMG2 and activating KLK3; cleave desmoglein DSG1, resulting in shedding of superficial keratinocytes from the skin surface; and play a role in tumour progression by affecting growth, invasion and angiogenesis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein.
Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease. Genomics 1999;62:251-9.
Molecular characterization of zyme/protease M/neurosin, a hormonally-regulated kallikrein-like serine protease. Genomics 1999;62:251-9.
PSA is a kallikrein-like serine protease crucial to the processing of various polypeptide precursors to their bioactive forms (2).
Recently, we presented a preliminary report on PSA expression in neuroectodermal tumor-derived cell lines (SK-N-BE-2 and SK-N-MC), which typically are composed of heterogeneous cellular subpopulations including neuroblastic and nonneuronal epithelial-like cells (17), and indicated that these brain tumor cell lines can produce and secrete this kallikrein-like serine protease (18).
The present multidisciplinary results, together with our previous observations (18), add support to the notion that PSA is a widespread kallikrein-like serine protease and focuses attention on the novel PSA expression by human neoplastic brain tissue.
(1) on the prostate-specific antigen (PSA) immuno-reactivity of cerebrospinal fluids, in which the authors report positive results for this kallikrein-like serine protease in ~7% of patients affected by various neurological disorders, suggesting that PSA could originate from the brain tissue.
Moreover, the higher amount of both the PSA fractions in culture media of the SK-N-MC cells is consistent with the capability of this cell line to more actively secrete this kallikrein-like serine protease in respect to the other neuroblastoma cell line, after a period 3-5 days of in vitro culture.