kallikrein

(redirected from Kallikrein-kinin system)
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kallikrein

 [kal″ĭ-kre´in]
any of several serine endopeptidases that cleave kininogens to form kinins.
plasma kallikrein a hydrolytic enzyme of the plasma that cleaves HMW (high-molecular-weight) kininogen to produce bradykinin. It also activates several blood coagulation factors and plasminogen. It is formed from prekallikrein by activated coagulation factor XII.
tissue kallikrein a hydrolytic enzyme that cleaves LMW kininogen to produce kallidin. It and closely related forms are found in tissues and various glandular secretions such as lymph, pancreatic juice, urine, and saliva.

kal·li·kre·in

(kal'i-krē'in),
A group of enzymes (for example, plasma, tissue, pancreatic, urinary, or submandibular kallikrein) that converts kininogen by proteolysis to bradykinin or kallidin. Trypsin and plasmin can also effect the conversion. Plasma kallikrein activates factor XII and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.

KLK4

A gene on chromosome 19q13.41 that encodes a serine protease expressed in the prostate.

Molecular pathology
Mutations of KLK4 cause amelogenesis imperfecta hypomaturation type 2A1.

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes (e.g., plasma, tissue, pancreatic, urinary, submandibular kallikrein) that can convert kininogen by proteolysis to bradykinin or kallidin; trypsin and plasmin can also effect the conversion; plasma kallikrein activates the Hageman factor and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.
Synonym(s): kininogenase, kininogenin.

Kallikrein

Any of a group of compounds in the body known as serine endopeptidases that help to break down proteins into smaller units. Prostate-specific antigen belongs to this group of chemicals. A recently discovered kallikrein may be useful as a biomarker for ovarian cancer.
Mentioned in: Ovarian Cancer

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes that can convert kininogen by proteolysis to bradykinin or kallidin.
References in periodicals archive ?
Su, "Different cross-talk sites between the reninangiotensin and the kallikrein-kinin systems," Journal of the Renin-Angiotensin-Aldosterone System, vol.
(ii) IL-17 activates the kallikrein-kinin system and facilitates the degradation of ECM proteins via upregulation of matrix-degrading enzymes such as matrix-degrading enzyme-2 and tissue plasminogen activator.
Meanwhile, both KEGG analysis and literature retrieval revealed that the two proteins were involved in kallikrein-kinin system (KKS).
It is predominantly influenced by the activity of three regulatory systems: the renin-angiotensin-aldosterone system, the prostaglandin system, and the kallikrein-kinin system. The latter two are a part of the renal vasodilator system, whereas the renin-angiotensin system represents the renal vasoconstrictor, with the vasodilator systems modulating vasoconstrictive effects of angiotensin II on one hand, and angiotensin II stimulating the secretion of vasodilatory components on the other, which prevents substantial increase in the renal vascular resistance.
The contact or kallikrein-kinin system is a network of proteins that modulate inflammation, blood pressure, coagulation, and pain.
Topics of specific papers include regulation of cardiovascular control mechanisms, inflammation, aldosterone and vascular damage, calcitonin gene-related peptides and hypertension, the renal dopaminergic system, salt sensitivity, insulin resistance, fatty acids, cell signaling, goal-oriented hypertension management, the role of nitric oxide, the Kallikrein-Kinin system, sex steroids, and the lipoxygenase system in the vasculature.
With 250 peer-reviewed publications in PubMed, his is a worldwide expert in regenerative cardiovascular medicine with significant research interest in the role of kallikrein-kinin system in angiogenesis and vascular biology.
Status of the kallikrein-kinin system, proteinase inhibitors, and nonspecific resistance factors in patients with chronic kidney failure on haemodialysis as well as kidney transplant recipients.
Kleinschnitz, "Ischemic stroke and traumatic brain injury: the role of the kallikrein-kinin system," Progress in Neurobiology, vol.
Both kallikrein-kinin system (KKS) and renin-angiotensin system (RAS) have been implicated in the pathogenesis of diabetic nephropathy (DN) [25, 26].