KLK7

(redirected from kallikrein 7)

KLK7

A gene on chromosome 19q13.3 that encodes a serine protease that catalyses the degradation of intercellular cohesive structures in the cornified layer of the skin during the normal shedding of cells from the skin surface. KLK7 may play a role in activating precursors of inflammatory cytokines.
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References in periodicals archive ?
Kallikrein 1 activates pro-MMP-2 and pro-MMP-9 (89) and kallikrein 7 activates pro-MMP-9 by cleaving its C-terminus.
To study the material's impact on the epidermis, at 0.25%, Iris ISO significantly increases the expression of transglutaminase 1 by 246%, of kallikrein 7 by 293% and of kallikrein 5 by 149%.
Development of an immunofluorometric assay and quantification of human kallikrein 7 in tissue extracts and biological fluids.
Further evidence has shown that human tissue kallikrein 7 (KLK7) [6] mRNA is significantly up-regulated in ovarian tumors (20, 21).
Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma.
The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells.
Because the HSCCE gene (a) is located next to other members in the human kallikrein family, (b) has the same genomic organization and intron phase as other members of this family and (c) has significant homology to other members of the family in both the DNA and amino acid sequences (7), HSCCE is now considered to be a member of the human kallikrein family and has been given a new name, KLK7 for the gene and human kallikrein 7 (hK7) for the protein (8).