KLK6

(redirected from kallikrein 6)

KLK6

A gene on chromosome 19q13.3 that encodes a serine protease that catalyses amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins (such as fibronectin, laminin, vitronectin and collagen). It may be involved in regulating axon outgrowth following spinal cord injury. KLK6 may play a role in invasion and metastasis.

Molecular pathology
KLK6 degrades alpha-synuclein, preventing its polymerisation, suggesting a role in the pathogenesis of Parkinson disease and other synucleinopathies.
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References in periodicals archive ?
TaqMan gene expression assays used were Hs00160519_m1 (kallikrein 6, KLK6), Hs00173611_m1 (kallikrein 10, KLK10), Hs00234579_m1 (matrix metalloproteinase 9, MMP9) and Hs99999905_m1 (glyceraldehyde 3-phosphate dehydrogenase, GAPDH).
In the conditioned cell culture medium from UMSCC1 cells with higher expression of miR-375, the most significantly reduced secreted proteases were a group of serine proteases known as kallikreins: kallikrein 5, kallikrein 6, kallikrein 10, and kallikrein 13.
Measurement of Kallikrein 6 (KLK6) in Circulating Plasma by ELISA.
Chung et al., "Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer," Cancer, vol.
Transcriptional upregulation of human tissue kallikrein 6 in ovarian cancer: clinical and mechanistic aspects.
Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications.
Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin.
Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma.
[5] Nonstandard abbreviafions: CaP, prostate cancer; ACN, acetonitrile; CM, condifioned medium; FPLC, last performance liquid chromatography; hK5, human kallikrein 5 protein; hK6, human kallikrein 6 protein; hK11, human kallikrein 11 protein; MS/MS, tandem mass spectrometry; PSA, prostate-specific anfigen; SAX, strong anion exchange; TBST, Tris-buffered saline with Tween 20.
Human kallikrein 6 (zyme/protease M/neurosin): a new serum biomarker of ovarian carcinoma.
The human kallikrein 6 (KLK6)[3] gene, which encodes for hK6 protein, was cloned independently by three groups.
The spectrum of human kallikrein 6 (zyme/ protease M/neurosin) expression in human tissues as assessed by immunohistochemistry.