kallikrein


Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.

kallikrein

 [kal″ĭ-kre´in]
any of several serine endopeptidases that cleave kininogens to form kinins.
plasma kallikrein a hydrolytic enzyme of the plasma that cleaves HMW (high-molecular-weight) kininogen to produce bradykinin. It also activates several blood coagulation factors and plasminogen. It is formed from prekallikrein by activated coagulation factor XII.
tissue kallikrein a hydrolytic enzyme that cleaves LMW kininogen to produce kallidin. It and closely related forms are found in tissues and various glandular secretions such as lymph, pancreatic juice, urine, and saliva.

kal·li·kre·in

(kal'i-krē'in),
A group of enzymes (for example, plasma, tissue, pancreatic, urinary, or submandibular kallikrein) that converts kininogen by proteolysis to bradykinin or kallidin. Trypsin and plasmin can also effect the conversion. Plasma kallikrein activates factor XII and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.

KLK4

A gene on chromosome 19q13.41 that encodes a serine protease expressed in the prostate.

Molecular pathology
Mutations of KLK4 cause amelogenesis imperfecta hypomaturation type 2A1.

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes (e.g., plasma, tissue, pancreatic, urinary, submandibular kallikrein) that can convert kininogen by proteolysis to bradykinin or kallidin; trypsin and plasmin can also effect the conversion; plasma kallikrein activates the Hageman factor and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.
Synonym(s): kininogenase, kininogenin.

Kallikrein

Any of a group of compounds in the body known as serine endopeptidases that help to break down proteins into smaller units. Prostate-specific antigen belongs to this group of chemicals. A recently discovered kallikrein may be useful as a biomarker for ovarian cancer.
Mentioned in: Ovarian Cancer

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes that can convert kininogen by proteolysis to bradykinin or kallidin.
References in periodicals archive ?
These data indicate that though three kallikrein therapeutic regimens all can attenuate the neurological deficits in cerebral ischemic mouse model, kallikrein treatment starting at 8 h has the best efficacy.
Chao, "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis," Biochimica et Biophysica Acta, vol.
In contrast, we found that there was a reduction in the levels of specific proteases, including kallikrein 6, kallikrein 10, and MMP-9.
Renal Immunoreactivity of Kallikrein. Figure 3 shows the immunoreactivity of kallikrein predominantly localized in renal tubular cells and generally negative in glomeruli.
Utsunomiya et al., "Clinicopathologic and biological significance of Kallikrein 6 overexpression in human gastric cancer," Clinical Cancer Research, vol.
Kang and colleagues hypothesized that gene silencing by methylation of the KLK1 gene promoter and thus the subsequent decrease of urine kallikrein may be associated with established AKI.
Studies in the lab of Joslin Investigator Edward Feener have pinpointed a new mechanism involving a protein called plasma kallikrein that interferes with the normal clotting process in the brain following blood vessel injury with diabetes.
(5) This study used salivary kallikrein, an enzyme, as its marker and attempted to determine if there were significant differences between healthy individuals, individuals with benign lesions, and subjects diagnosed with breast and gastrointestinal malignancies.
Scarisbrick previously found elevated levels of "KLK6" (a newly identified member of the kallikrein enzyme family) in areas of damage found in tissue samples from people with MS.
We hypothesise that her intraoperative deterioration resulted from acute elevation of kallikrein released during surgical manipulation of the tumour.