ProANP 1-30 is the long-acting natriuretic peptide, proANP 31-67 has vasodilation properties, and proANP 79-98 or kaliuretic
peptide, is involved in potassium excretion.
When aldosterone or other kaliuretic
factors fail to maintain potassium homeostasis, extracellular [[K.
The aim of this study was to assess diuretic, natriuretic and kaliuretic
activities of these medicinal plants.
Natriuretic and kaliuretic
activities of guanylin and uroguanylin in the isolated perfused rat kidney.
The leaves of the plant have been used as an oral contraceptive and sweetener (Mazzei-Planas & Kuc, 1968), a hypoglycemic agent (Curi et al, 1986; Gregersen et al, 2004), a diuretic, natriuretic and kaliuretic
(Melis 1992, 1995; Kinghorn & Soejarto, 1985), and a hypotensive agent (Soejarto et al, 1982; Kinghorn & Soejarto, 1985; Melis, 1992; Haebisch, 1992; Hsu et al, 2002).
In the isolated perfused rat kidney, both peptides elicit strong natriuretic and kaliuretic responses (Fonteles et al.
Renal metabolism of this peptide may also explain why uroguanylin is more potent as natriuretic and kaliuretic than guanylin in the isolated perfused rat kidney (Fonteles et al.
and kaliuretic at doses of 350 and 500 mg/kg body wt.
dose of corn silk used in Protocol 1, the diuretic and kaliuretic dose, on glomerular and tubular function parameters.
These data agree closely with the results of other studies (21-23), indicating that RIAs for the assay, respectively, of the long-acting natriuretic peptide, the vessel dilator peptide, and the kaliuretic peptide actually also recognize the whole N-terminal [proANP.
The assays of long-acting natriuretic peptide, vessel dilator peptide, and kaliuretic peptide, released simultaneously with ANP, should be also considered to be a marker of atrial stretch and overload.
Three peptides from the ANF prohormone NHZterminus are natriuretic and/or kaliuretic