kainic acid


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kai·nic ac·id

(kā-in'ik as'id),
A glutamate analogue that exhibits powerful and long-acting excitatory and toxic activity on neurons. In neurobiology, it is used as a research tool to destroy neurons and as an activator of glutamate receptors; it has been used as an anthelmintic against nematodes.

kainic acid

Neurophysiology An excitatory neurotoxin, which stimulates glutamate receptors. See Kainate receptors.
References in periodicals archive ?
kainic acid; LLOQ, lower limit of quantification; NHBA.
Kainic acid (KA; Tocris, Bristol, UK) was used as an excitotoxin in the present study.
Wu et al., "Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats," Seizure, vol.
Kainic acid and synaptic transmission in the stellate ganglion of the squid.
The different groups responded differently to certain seizure triggers 6 the fasting mice had seizures in response to mild electric shocks, but tolerated injections of the nervous system stimulant kainic acid. The researchers observed the opposite phenomenon in ketogenic mice; they could tolerate electricity, but were triggered by the kainic acid.
Statins have been shown to be neuroprotective in a group of animal disease models and clinical studies.11,17 Statins are shown to prevent hippocampal neuron death in kainic acid (KA), pilocarpine, pentylentetrasole and quinolinic acid (QA)-induced epileptic seizures.11,13
There was minimal cross-reactivity in this assay with glutamine, glutamic acid, kainic acid, epi- or iso-DA.
The four main families of excitatory amino acid receptors are [alpha]-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPA), N-methyl-D-aspartate receptors (NMDA), metabotropic glutamate receptors, and kainic acid receptors.
Halagappa and Mattson took the work a step further by designing an experiment in which mice that had been on the four different diets were exposed to a neurotoxin called kainic acid, which is known to damage nerve cells in the hippocampus, a brain region involved in learning and memory.
Spatio-temporally differential expression of the mRNA for brain- and skin-type but not heart-type fatty acid-binding proteins following kainic acid systemic administration in the hippocampal glia of adult rats.
However, BNIP3 expression was increased dramatically in vivo when kainic acid, a structurally rigid analog of the excitatory amino acid glutamic acid was injected into rat striata, or when traumatic brain injury was introduced.