kainic acid


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kai·nic ac·id

(kā-in'ik as'id),
A glutamate analogue that exhibits powerful and long-acting excitatory and toxic activity on neurons. In neurobiology, it is used as a research tool to destroy neurons and as an activator of glutamate receptors; it has been used as an anthelmintic against nematodes.

kainic acid

Neurophysiology An excitatory neurotoxin, which stimulates glutamate receptors. See Kainate receptors.
References in periodicals archive ?
Testing Cross-Reactivity of the ELISA Against Glutamine, Kainic Acid and Putative Isomers Epi-DA and Iso-DA
The value of this first in vitro evaluation is supported by previous studies showing that the oral administration of PC in rats reduces microglial and astroglial activation induced by kainic acid (Rimbau et al.
Young male Fischer-344 rats were fed a diet containing 2% blueberry (BB) extract or control diet for at least 8 weeks and then received bilateral hippocampal injections of kainic acid (KA 200 ng/0.
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.
Epileptic seizure model was established by intraperitoneal injection of kainic acid (KA) in rats.
In the current study, we investigated whether polyphenols in blueberries can reduce the deleterious effects of inflammation induced by central administration of kainic acid by altering the expression of genes associated with inflammation.
By measuring a variety of oxidative indexes (including levels of 8-OH-dG), earlier studies have shown that melatonin effectively protects DNA from oxidative damage induced by a number of free-radical-generating agents including safrole, kainic acid, lipopolysaccharide, ferric nitrilotriacetate, ischemia/reperfusion, and ionizing radiation both in vitro and in vivo (31-36).
Effects ofginsenoside Rd and decursinol on the neurotoxic responses induced by kainic acid in mice.