kainate receptor


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kai·nate re·cep·tor

a type of glutamate receptor that participates in excitatory neurotransmission.
References in periodicals archive ?
Our previous study showed that GluR5-containing kainate receptors (non-NMDA glutamate receptor) regulate the inhibitory synaptic transmission through endogenous glutamate; therefore, we tested how neonatal propofol and etomidate exposure affect endogenous glutamatergic tonic regulation to inhibitory synaptic transmission in P90 approximately rats.
This fine balance between phosphorylation and SUMOylation is dependent on brain activity levels where damaging activity that occurs during stroke or epilepsy will enhance SUMOylation and therefore reduce kainate receptor function to protect nerve cells.
Bidirectional modulation of GABA release by presynaptic glutamate receptor 5 kainate receptors in the basolateral amygdala.
1992) and (b) pharmacological treatments that affected presynaptic kainate receptors (Lauri et al.
81) KYNA is a tryptophan metabolite that has selective activity against NMDA, quisqualate, and kainate receptors in the central nervous system.
It disrupts normal neurochemical transmission in the brain by binding to certain glutamate receptors, the so-called kainate receptors, of neuronal cells.
BDNF enables the release of glutamate by prohibiting the function of kainate receptors, which slow down the development of the preforms of the synapses.
Particularly the NMDA receptors are the most sensitive to the effects of ethanol, even if AMPA and kainate receptors are also modulated by this drug (Dodd, Beckmann, Davidson & Wilce, 2000).
In turn, kainate receptors apparently play a role only in STM acquisition, and NMDA receptors seem to act in the LTM acquisition phase (Barker et al.
iGluR-NMDA belongs to the ionotropic receptors family that has three functionally different types: a-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPA), high-affinity kainate receptors and N-Methyl-D-Aspartate (iGluR-NMDA) receptors.
The protein's attachment or withdrawal helps control the ability of kainate receptors to regulate signals passed along synapses linking the brain's millions of nerve cells.
The simple classification of receptors as ionotropic or metabotropic also is beginning to blur as reports accumulate that, for example, activation of ionotropic kainate receptors may also produce a second-messenger cascade.