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Renin, released from juxtaglomerular cells, causes the proteolytic cleavage of angiotensinogen to angiotensin I which is also a target of proteolytic cleavage.
It is generally accepted that the majority of circulating renin originates from the kidney (mainly from juxtaglomerular cells).
Renin is synthesized and secreted into the blood exclusively by the juxtaglomerular cells
of the kidney from prorenin, an inactive precursor, which is produced not only by the kidney, but by other tissues, including the adrenal glands, gonads, and the uteroplacental unit (2).
As a result of direct sympathetic stimulation of the juxtaglomerular cells
and ischemia initiating the rennin-angiotensin cascade, renin and eventually AII are produced.
These granular smooth muscle cells of the afferent arteriole are called juxtaglomerular cells
, which synthesize and store renin, a proteolytic enzyme.