Loss of chromosomes 9 and 11 may be recurrent chromosome imbalances in juxtaglomerular
Pathological diagnosis was juxtaglomerular
cell tumor, malignant.
() In response to a decrease in arterial blood pressure, the proteolytic enzyme renin releases from the juxtaglomerular
cells in the kidney and acts on its inactive substrate angiotensinogen (Ang) to form the decapeptide Ang I.
The glomerular layer consists of synapses between the terminals of the olfactory nerve and the dendrites of mitral, periglomerular, and tufted cells, as well as a heterogeneous population of juxtaglomerular
neurons; in contrast, the granular cell layer is densely composed of GABA-ergic inhibitory neurons .
In the olfactory bulb, the majority of SVZ-derived neuroblasts become axon-less GABAergic granule neurons while a minority become GABAergic periglomerular neurons and even fewer become short-axon glutamatergic juxtaglomerular
Rennin is secreted from juxtaglomerular
cell, which could activate liver to produce Ang I, and then transferred into Ang II, and Ang III transferred from Ang II.
Viberti, "The structure of glomeruli and juxtaglomerular
arterioles in the early phase of diabetic nephropathy--relationship between progression and metabolic control," Contributions to Nephrology, vol.
Targeted vitamin D receptor expression in juxtaglomerular
cells suppresses renin expression independent of parathyroid hormone and calcium.
84, the secretion of renin from juxtaglomerular
cells is inhibited by Ca.
This has effects throughout the kidney economy (vessels, tubules, juxtaglomerular
apparatus, myocytes) impairing its autoregulatory capacity, evidenced by proteinuria, HT and renal fibrosis, becoming a positive feedback pathophysiology.
Through the signaling of kidney baroreceptors located in the afferent arterioles, juxtaglomerular
apparatus cells increase or reduce the renin secretion in response to decreased or increased circulating blood volume or renal blood flow, respectively.
Activation of adrenergic receptors in the kidney is also important for modulating blood pressure as neuronal noradrenaline promotes the release of renin from the juxtaglomerular
apparatus, sodium retention, and vasoconstriction.