Caption: Figure 2: Cx channels form the intercellular junctional complex
. TJ contains a complex of proteins spanning the intercellular cleft (occludin and claudin).
Apolar tissue: cells with polarities of any orientation, without apical belt-shaped junctional complexes
, being submerged in the extracellular matrix (Rieger, 1986).
Dismantling of the apical junctional complex
during EMT is necessary for epithelial cells to detach from one another and migrate away as individuals (Boyer et al., 2000).
Note the basement membrane (B) and junctional complex
Multiple abnormalities have been elucidated in junctional complexes
of cancerous tissues [19, 20].
At higher magnification, the plasma membrane of these cells possessed abundant microvillar projections with junctional complexes
joining adjacent cells (Figure 4(d)).
The basal plasmalemma showed tight junctional complexes
with adjacent cell membrane and in certain areas distinct intercellular canaliculi were present between the cells.
Furthermore, the mechanisms that affect adhesion molecules and junctional complexes
and their significance in primary sclerosing cholangitis and extrahepatic cholestasis are elucidated.
With his collaborators, Palade described a transport system across the endothelium and identified the so-called Weibel-Palade bodies which play a role in coagulation and inflammation; he also described the neuronal synapses, the tight junctions and junctional complexes
in glomerular cells and the secretory pathways of proteins from the endoplasmic reticulum towards the extracellular compartment.
The junctional complexes
between follicular cells in the apico-lateral borders were quite distinct with a prominent tight jun ction from which single cilium sometimes projected from it into the luminal colloid (Fig.1D).
Several junctional complexes
, including adherens junctions and tight junctions, participate in this process .