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JUN

A gene on chromosome 1p32-p31 that is the putative transforming gene of avian sarcoma virus 17, which interacts directly with specific target DNA sequences to regulate gene expression.

Molecular pathology
JUN maps to a chromosome region involved in both translocations and deletions in cancer.

jun

(joon)
A family of oncogenes that can transform some normal cells (e.g., rat embryo cells) into cancer cells. All members of this family can bind to activating protein-1 (AP-1) sites and to specific DNA sequences. See: oncogene; transformation
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