Minimum inhibitory concentrations (MICs) were measured by using the microdilution method in triplicate for the following antimicrobial agents: erythromycin, clarithromycin, azithromycin, roxithromycin, josamycin
, tetracycline, doxycycline, levofloxacin, moxifloxacin, and ciprofloxacin.
ketoconazole, itraconazole, erythromycin, clarithromycin, josamycin
, and protease inhibitors (ritonavir, indinavir, and nelfinavir).
Determination of josamycin
in plasma, erythrocytes and leukocytes via high-performance liquid chromatography by direct injection of plasma or homogenized blood cells, using alternation sample clean-up columns.
Cyclines and fluoroquinolones were contraindicated because of her pregnancy, and the patient had a history of maculopapular rash after taking josamycin
A triple disk-diffusion test with erythromycin, clindamycin, and josamycin
was performed to test resistance inducibility.
All patients fully recovered with doxycycline or, for the pregnant patient, josamycin