X-rays show joint-space narrowing
with OA, but no erosions or cysts.
The investigational drug also seemed to slow joint-space narrowing
, compared with baseline values, with the suggestion that it may even increase joint space width.
Participants needed to have a knee OA incidence with a K&L grade of at least 2; incidence of clinical knee OA according to clinical and radiographic American College of Rheumatology criteria; or joint-space narrowing
of at least 1.0 mm.
Arthroscopic debridement is not recommended for patients with advanced arthritis, significant joint-space narrowing
, marked fibrosis, or mechanical deformity.
But two trials concurrent with GAIT reported less knee joint-space narrowing
over years of taking 800 mg of chondroitin daily.
The arthropathy superficially resembles degenerative joint disease, with joint-space narrowing
, sclerosis, and osteophytosis; but, in hemochromatosis, it reveals definite characteristics in its distribution and appearance that enable it to be recognized on radiographic examination.
Those who took this nutrient had no increase in joint-space narrowing
. Those who took the placebo, did.
Those taking glucosamine showed less joint-space narrowing
on X-rays than those taking placebos.
The difference in total 24-month progression between the two treatment arms was statistically significant for total SVdH score and erosion score, and for the extent of joint-space narrowing
. In addition, the difference in total SVdH score between months 12 and 24 for the two treatment arms was statistically significant.
Plain radiography may show joint-space narrowing
, osteophyte formation, and/or subchondral sclerosis, although radiography is often normal in early disease.
In the first trial, the 106 patients on placebo had progressive joint-space narrowing
, with a mean joint-space loss after 3 years of -0.31 mm (95% = -0.48 to -0.13).