itai-itai disease


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i·tai-·i·tai dis·ease

a form of cadmium poisoning described in some Japanese people, characterized by renal tubular dysfunction, osteomalacia, pseudofractures, and anemia, caused by ingestion of contaminated shellfish or other sources containing cadmium.
A form of renal osteodystrophy—osteomalacia with marked bone pain and painful fractures—described in multiparous Japanese women due to cadmium accumulation in bone, caused by industrial pollutants
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References in periodicals archive ?
Although first reported in French workers by Nicaud et al (7), toxic effects of Cd on the bones really became evident with the outbreak of the Itai-Itai disease in the Cd-polluted area of Toyama, Japan, after World War II.
The toxic effect of cadmium on bone became evident at the outbreak of Itai-itai disease in Japan, where severe renal and skeletal damage in women was associated with consumption of heavily cadmium-polluted rice (Kjellstrom 1992).
1999), and in line with the fact that those affected by the Itai-itai disease were mainly women after menopause (Kjellstrom 1986).
Cadmium, a toxic metallic element, is known to be the cause of Itai-itai Disease, considered to be a type of acquired Fanconi Syndrome characterized by kidney dysfunction and osteomalacia, which plagued a number of people, mainly women, in Toyama Prefecture in the 1950s.
Cadmium is known to be the cause of Itai-itai Disease, considered to be a type of acquired Fanconi Syndrome characterized by kidney dysfunction and osteomalacia, which plagued a number of people, mainly women, in Toyama Prefecture in the 1950s.
Residents of low-lying areas along the river in Toyama Prefecture were the main people affected by the condition, which caused severe twinges and became known as the Itai-Itai Disease.
This challenges the previous view that the concurrent kidney and bone damage seen in Japanese itai-itai disease patients was the result of Cd toxicity in combination with nutritional deficiencies, notably, of zinc and calcium.
There were reports of women who suffered from symptoms similar to itai-itai disease near zinc mines in southern China.
Long-term exposure to cadmium may cause kidney and bone damage (1); the most well-known example is the itai-itai disease in Japan.