IVD

(redirected from isovaleryl)
Also found in: Encyclopedia.

IVD

A gene on chromosome 15q14-q15 that encodes isovaleryl-CoA dehydrogenase, a mitochondrial matrix enzyme that catalyses the third step in leucine catabolism.

Molecular pathology
Defects in IVD leads to a toxic accumulation of isovaleric acid in the brain or isovaleric acidaemia.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

diagnostic

Pert. to a diagnosis.

in vitro diagnostic

Abbreviation: IVD
1. Any device, reagent, material, or system designed for use in the laboratory diagnosis of disease or health status. The term also refers to a general category of entities that are highly and specifically regulated by the U.S. Food and Drug Administration and other regulatory bodies.
2. The laboratory analysis of body substances (e.g., blood, saliva, stool, or urine) for specific analytes indicative of disease.

in vitro diagnostic

Abbreviation: IVD
1. Any device, reagent, material, or system designed for use in the laboratory diagnosis of disease or health status. The term also refers to a general category of entities that are highly and specifically regulated by the U.S. Food and Drug Administration and other regulatory bodies.
2. The laboratory analysis of body substances (e.g., blood, saliva, stool, or urine) for specific analytes indicative of disease.
See also: diagnostic
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
The most notable feature that differed between the 2 was the presence of isovaleryl carnitine (IV-carnitine), which was increased by a factor of 5.1 in MMA but did not differ from normal in PA.
One of the most significant differentiating features had an m/z of 246.17 and was identified as isovaleryl carnitine ([C.sub.12][H.sub.23]N[O.sub.4]) based on accurate mass and MS/MS data (see Table 1 in the Data Supplement that accompanies the online version of this article at http:// www.clinchem.org/content/vol53/issue12).
More significantly, isovaleryl carnitine was increased by a factor of 2.8 in MMA vs PA, with a P value of 9.7 x [10.sup.-8]) (Fig.
In this study, metabolites such as unsaturated acylcarnitines, isovaleryl carnitine, and ybutyrobetaine were associated with MMA and PA.
Because this technique is not suitable for detection of acetyl and isovaleryl conjugates of tryptophan, lysine, histidine, and asparagine because of their polar characteristics, we identified and quantified these metabolites by electrospray tandem mass spectrometry (ESI-MS-MS).
Formerly unidentified isovaleryl conjugates of the following amino acids were detected and identified in the urine of IVA patients: [alpha]-aminobutyric acid, aspartic acid, serine, phenylalanine, threonine, valine, leucine, and tyrosine by GC-MS; and N-isovalerylasparagine,-histidine,-lysine, and-tryptophan by ESI-MS-MS.
Cloning, nucleotide sequence, and expression of an isovaleryl pepstatin-insensitive carboxyl proteinase gene from Pseudomonas sp.