isovaleric acid


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i·so·va·ler·ic ac·id

(ī'so-vă-ler'ik as'id, -lēr'ik),
3-Methylbutyric acid; a metabolic intermediate in oxidative processes; elevated in cases of isovaleric acidemia.

isovaleric acid

/iso·va·ler·ic ac·id/ (i″so-vah-ler´ik) a carboxylic acid occurring in excess in the plasma and urine in isovalericacidemia.

isovaleric acid

[-vəler′ik]
Etymology: Gk, isos + L, valeriana, herb, acidus, sour
a fatty acid with a pungent taste and disagreeable odor that is found in valerian and other plant products, as well as in cheese. It also occurs as a metabolite of the amino acid leucine and is found in the sweat of feet and in the urine of patients with smallpox, hepatitis, and typhus. It has been used commercially in a variety of drugs, perfumes, and flavorings. Isovaleric acidemia occurs in patients who have abnormally high levels of isovaleric acid in the blood and urine as a result of an inherited deficiency of the enzyme isovaleryl coenzyme A dehydrogenase. The condition is treated with diets that contain low-leucine foods. Also called isopentoic acid, isopropylacetic acid.
References in periodicals archive ?
D Aliyu and Nwabueze (2007) synthesis and solution studies of coppor (11) valeric and isovaleric acid hydrazide in aqueous, medium J.
Analysis of the patient's plasma for short-chain fatty acids will reveal elevated isovaleric acid, isovalerylglycine, isovaleryl carnitine, and 3-hydroxyisovaleric acid.
Prior studies by others had awarded that distinction to steroids and isovaleric acid.
Isovaleric acidemia (IVA) [4] (OMIM #243500) is caused by a defect in leucine catabolism due to deficiency of isovaleryl-coenzyme A (CoA) dehydrogenase, leading to the accumulation of free isovaleric acid, 3-hydroxyisovaleric acid, N-isovalerylglycine, and isovalerylcarnitine (C5).
When leucine is not used properly, it builds up as isovaleric acid and other harmful substances in the blood and urine that are toxic or poisonous.
Isovaleric acid gets credit for the rancid and horsy elements.
5%), bButyric acid (99%), isobutyric acid (99%), valeric acid (99%), isovaleric acid (99%), indole (99%), skatole (98%) and p-cresol (99%).
Racial and cross-cultural differences have been reported for isovaleric acid (1.
The alfalfa hay/ grain diet produced significantly higher pH, acetic, propionic and isovaleric acid concentrations when compared to the bromegrass hay diet.
Valeric and isovaleric acid concentrations with yeast treatment were higher than that in control solutions at 8, 12, and 24 h (p<0.