isovaleric acid


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i·so·va·ler·ic ac·id

(ī'so-vă-ler'ik as'id, -lēr'ik),
3-Methylbutyric acid; a metabolic intermediate in oxidative processes; elevated in cases of isovaleric acidemia.

isovaleric acid

/iso·va·ler·ic ac·id/ (i″so-vah-ler´ik) a carboxylic acid occurring in excess in the plasma and urine in isovalericacidemia.

isovaleric acid

[-vəler′ik]
Etymology: Gk, isos + L, valeriana, herb, acidus, sour
a fatty acid with a pungent taste and disagreeable odor that is found in valerian and other plant products, as well as in cheese. It also occurs as a metabolite of the amino acid leucine and is found in the sweat of feet and in the urine of patients with smallpox, hepatitis, and typhus. It has been used commercially in a variety of drugs, perfumes, and flavorings. Isovaleric acidemia occurs in patients who have abnormally high levels of isovaleric acid in the blood and urine as a result of an inherited deficiency of the enzyme isovaleryl coenzyme A dehydrogenase. The condition is treated with diets that contain low-leucine foods. Also called isopentoic acid, isopropylacetic acid.
References in periodicals archive ?
49 Butyric acid Isovaleric acid Item mmol/kg Time (d) 0 0.
The concentrations of propionic acid, isobutyric acid, butyric acid, isovaleric acid and valeric acid were low and varied little throughout the incubation.
The use of carnitine and glycine is to prevent the build up of toxic metabolites, isovaleric acid, so that it can be excreted from the body.
The blood is checked for leucine and organic acid content, and the urine is checked for isovaleric acid bound to the carnitine and glycine.
The typical constituents of valerian roots are found to be valeric and isovaleric acid, monoterpenes ([alpha]-pinene, [alpha]-fenchene, camphene), monoterpenic esters (bornyl acetate, myrtenyl acetate, myrtenyl isovaleriate), oxygen containing sesquiterpenes, and valerian cyclopentanoid sesquiterpenes such as valerenal, valerenone, valerenol, valerenyl acetate, valerenic acid, and valerenyl isovalerate.
The basic oil components were isovaleric acid (0-2.
Deficiency of this enzyme results in accumulation of leucine catabolism byproducts, particularly isovaleryl carnitine, isovalerylglycine, 3-hydroxyisovaleric acid, and isovaleric acid itself.
The complexes of acetovaleric acid hydrazone [AVAH], acetylaldehyde valeric acid hydrazone [AAVAH], acetyl isovaleric acid hydrazone [AIVA] and acety aldehyde varaleric acid hydrazone [AAIVAH] complexes with Cu(II) and Ni(II) sulphate have been reported to be of distorted octahedral symmetry with a promising antibacterial activity (4).
The foul odor of isovaleric acid is the metabolic waste product of Staphylococcus epidermidis as it consumes leucine residues in human sweat.
nucleatum's byproducts of lipopolysaccharide, fimbriae, proteinases and at least five different short-chain fatty acids (SCFA): butyric acid, isobutryic acid, isovaleric acid, propionic acid and acetic acid.
This report segments the global carboxylic acids market as follows: Carboxylic Acids Market -- Product Segment Analysis Acetic acid Valeric acid Isovaleric acid Formic acid Propionic acid Butyric acid Isobutyric acid Citric acid Caproic acid Stearic acid Others (including benzoic acid) Carboxylic Acids Market & End-user Analysis Food & beverages Animal feed Pharmaceuticals Personal care & cosmetics Consumer goods Lubricants Others (including agrochemicals, textiles, chemical intermediates, rubber, etc.
Addition of CT from mangosteen-peel reduced the concentrations of acetic acid, propionic acid, butyric acid, isovaleric acid and increased the acetic:propionic ratio.