isotype switch

isotype switch

the process whereby the constant region gene of an antibody heavy chain is replaced with the constant region gene of another isotype, although the antigen-binding portion of the molecule is unchanged.
References in periodicals archive ?
In mouse models, Tfh cells are a central source of IL-21 in germinal centers of secondary lymphoid organs, providing cognate help to B cells in the germinal center dynamic microenvironment, acting specially on naive B cells to induce isotype switch to IgG and IgA (68).