Isotype switch | definition of isotype switch by Medical dictionary
the process whereby the constant region gene of an antibody heavy chain is replaced with the constant region gene of another isotype, although the antigen-binding portion of the molecule is unchanged.
References in periodicals archive
Molecular Signals for the Isotype Switch
Necessary for IgE Production
In a tumor model the combination of HER-2/neu genetic vaccine and TLR9 agonist showed potent antitumor activity associated with antibody isotype switch
and antibody-dependent cellular cytotoxicity activities.