isotype switch

isotype switch

the process whereby the constant region gene of an antibody heavy chain is replaced with the constant region gene of another isotype, although the antigen-binding portion of the molecule is unchanged.
References in periodicals archive ?
Molecular Signals for the Isotype Switch Necessary for IgE Production
In a tumor model the combination of HER-2/neu genetic vaccine and TLR9 agonist showed potent antitumor activity associated with antibody isotype switch and antibody-dependent cellular cytotoxicity activities.