isotype


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to isotype: idiotype, allotype

i·so·type

(ī'sō-tīp),
An antigenic determinant shared by all members of a class or subclass of an immunoglobulin molecule. Immunoglobulin isotypes include IgG, IgA, IgE, IgD, and IgM.
[iso- + G. typos, model]

isotype

(ī′sə-tīp′)
n.
1. A biological specimen or other element that is a duplicate of the holotype.
2. Any of the subclasses of immunoglobulins defined by the chemical and antigenic characteristics of their constant regions.

i′so·typ′ic (-tĭp′ĭk) adj.

isotype

[ī′sətīp]
an antigenic determinant that occurs in all members of a subclass of an immunoglobulin class. An antigenic determinant that is isotypic in one subclass may appear as an allotypic marker in another class.

i·so·type

(ī'sō-tīp)
An antigenic determinant (marker) that occurs in all members of a subclass of an immunoglobulin class.
[iso- + G. typos, model]

isotype

the antigenic variability between related proteins, e.g. between immunoglobulin classes of a single species.
References in periodicals archive ?
Salivary antibody isotype Age range IgM IgA (years) 4-6 7-11 12-16 4-6 7-11 12-16 n 26 84 59 26 84 59 Antibody titers 0.
Compared to isotype antibody, anti-ST2 treatment had no effect on airway responsiveness in [O.
This fraction was then multiplied by the corresponding HC isotype (total IgG, IgA, or IgM) concentration as measured by nephelometry to generate the M-protein concentration.
Likewise, the isotypes first innovated by Neurath and his colleagues at the Gesellschafts- und Wirtschaftsmuseum grew out of Neurath's desire to educate the public about social and economic conditions in the ultimate hope of bringing about a more rationally-organized economic system, where poverty and inequality would be overcome and people could maximize their happiness.
Two studies have mentioned that patients with renal failure of unknown cause, bone pain, small serum M-protein bands, or undefined Ig isotype should be suspected of having IgD multiple myeloma (4,13).
Isotype determination of produced anti-PSA mAbs using a homemade ELISA mAbs\Isotypes Heavy chain IgGl IgG2a IgG2b IgC3 IgA IgM 2G3-E2 0.
It examines the content of the process of transformation by investigating the original Isotype material attached to a project, the aim being to revive the notion of transformation within practice.
administration building, 900 m, 1989, Fleig 3601 (holotype, ICN 71921; isotype, H).
1,3,17,18) When samples with known monoclonal proteins were evaluated, interference rates have been reported as high as 46%, depending on the concentration and isotype of the monoclonal protein, and the specific test and assay methodology being evaluated.
The mechanism of benzimidazole resistance appears to involve mutations in the gene encoding AYTubulin isotype 1 (AYTubulin-1).
In Vienna, Neurath had also become interested in the way complex information can be communicated using simple icons and images, a method he called Isotype (International System of Typographical Picture Education).