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One of two or more atoms or molecules having the same electron arrangement, for example, N2 and CO.
[iso- + G. stereos, solid]
References in periodicals archive ?
or CO and N 2 and found that these compounds have analogous physical properties and thus characterized as different groups of isosteres as shown in Table-2.
At that time this concept was used to portray the resemblance of ions or molecules like O -2 x F - in terms of the same number of valance electrons and same number of atoms and prediction of similar physicochemical properties for isosteres having same net charge.
According to Grimm concept, an isoelectronic correlation can exist in each vertical column of Table-3, would signify a group of isosteres.
Erlenmeyer H (1932)-- Isosterism Concept Extension Erlenmeyer further extended the concept of isosterism [22] and reintroduced the term isosteres as atoms/elements, ions or molecules which exhibit similarity with respect to peripheral layers of electrons that is same number of electrons at the valance or peripheral level.
Table-4: Erlenmeyer Isosteres based on number of valance (peripheral) electrons.
1997) Difluorotoluene, a nonpolar isostere for thymine, codes specifically and efficiently for adenine in DNA replication.
In 2003, while considering Kool's Z-F and Q-F pairs, which are hydrophobic isosteres of the natural A-T pair, we found that the shape complementarity of these base pair is still imperfect, and the hydrogen atoms in the center on the pairing surface clash with each other (Fig.
The prior art also defined isosteres as atoms in which the peripheral layers of electrons can be considered identical, as is the case for bioisosteres CH and nitrogen (N).