isosorbide dinitrate


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to isosorbide dinitrate: prochlorperazine, Isosorbide mononitrate

i·so·sor·bide di·ni·trate

(ī'sō-sōr'bīd dī-nī'trāt),
A coronary vasodilator that acts via the formation of nitric oxide.

isosorbide dinitrate

(ī′sō-sôr′bīd′ dī-nī′trāt′)
n.
A vasodilator drug, C6H8N2O8, used to treat and prevent angina pectoris.

isosorbide dinitrate

[-sôr′bīd]
an antianginal agent. Its prototype is nitrogycerin.
indications It is prescribed as a coronary vasodilator in the treatment of angina pectoris and congestive heart failure and esophageal spasm caused by GI reflux.
contraindications Closed-angle glaucoma, known hypersensitivity to this drug, concurrent use of drugs for erectile dysfunction, narrow-angle glaucoma, head trauma, or severe anemia prohibits its use.
adverse effects The most serious effect is occasional marked hypotension. Flushing, headache, lightheadedness, and dizziness may also occur.

isosorbide dinitrate

Cardiology A venodilating nitrate used with hydralazine in CHF; ID ↓ cardiac filling pressure, ↑ exercise tolerance. See Nitrates.

isosorbide dinitrate

A drug used to prevent or relieve ANGINA PECTORIS and in to treat HEART FAILURE. The drug is on the WHO official list. Brand names are Angitak, Cedocard Retard, Isoket and Isotek Retard.

isosorbide dinitrate (ī´sōsor´bīd dīnī´trāt),

n brand names: Iso-Bid, Isotrate, Dilatrate-SR, Isordil;
drug class: nitrate antianginal; action: decreases preload/afterload, which is responsible for decreasing left ventricular end-diastolic pressure, systemic vascular resistance;
uses: chronic stable angina pectoris, prophylaxis of angina pain.
References in periodicals archive ?
Therefore we conducted this study to compare vasodilating effect of isosorbide dinitrate and propofol during rewarming on cardiopulmonary bypass.
Treatment with PE low dose and PE high dose as well as isosorbide dinitrate all significantly inhibited both the AMI-induced decrease in SOD activity and increase in MDA.
5 mg hydralazine hydrochloride and 20 mg isosorbide dinitrate, which have been approved separately for treating hypertension (hydralazine) and angina (isosorbide dinitrate) for more than 40 years.
The combination of isosorbide dinitrate and hydralazine induces regression of left ventricular remodeling in patients already treated with neurohormonal inhibitors," Dr.
A substantial quantity of potentially isosorbide dinitrate was found during a joint inspection at Euticals Limited, Sandycroft, by the Health and Safety Executive (HSE) and Environment Agency Wales.
the makers of fixed-dose isosorbide dinitrate and hydralazine (BiDil).
The fixed-dose combination of isosorbide dinitrate and hydralazine is the first product approved specifically for treating patients in a specific racial group--a development that has been both lauded as a significant advance that could help save the lives of many African Americans with heart failure and criticized as scientifically unjustified and generating a racial stigma.
Alyn and Deeside MP Mark Tami was speaking after a large amount of Isosorbide Dinitrate (ISDN Pure) was found at pharmaceuticals manufacturer Euticals Limited in Sandycroft.
NEW ORLEANS -- Treating patients with advanced heart failure with the combination of isosorbide dinitrate and hydralazine in addition to standard therapy led to clinical improvement and a drop in deaths during an average of just 10 months of treatment.
Flintshire County Council chief executive Colin Everett said a "substantial quantity of potentially explosive pharmaceutical material" called Isosorbide Dinitrate (ISDN Pure) - was identified on the site.
The fixed-dose combination of isosorbide dinitrate and hydralazine is the first product approved specifically for treating patients in a specific racial group--a development that has been lauded as a significant advance that could help save the lives of many African Americans and criticized as scientifically unjustified and generating a racial stigma.