isoprostane


Also found in: Wikipedia.

i·so·pros·tane

(ī-sō-pros-tān),
Compound derived from the free radical oxidation of arachidonic acid; resembles in some manner the prostoglandins. Elevated levels may be associated with atherosclerosis, hepatorenal syndrome, rheumatoid arthritis, and carcinogenesis.

isoprostane

(ī-sō-prŏs′tān″)
Any compound similar to prostaglandin that can be used as a marker for tissue damage caused by oxygen-derived free radicals. It is measured in human blood through the use of immunoassay technique and may enhance the study of diseases caused by oxidative stress.
References in periodicals archive ?
Although isoprostane, nitrotyrosine and other markers of OS are also available in research, MDA is the most commonly used parameter of OS because of easy methodology.
Markers of lipid--aldehydes, dialdehydes, methylglyoxal, hexenal derivatives, nonenal, and isoprostane.
It was reported to prevent cisplatin-induced nephrotoxicity via a decrease in MDA, 8- isoprostane, multidrug resistance-associated proteins and increasing organic cation transporters.
Before and just after the event, the scientists measured the compound isoprostane in blood and urine samples as a newly established, state-of-the-art marker of oxidative stress.
There was positive correlation between serum total cholesterol with serum Hcys and plasma isoprostane (r=0.
Placenta isoprostane is significantly increased in preeclampsia.
Peptides 4F and Ac-hEl8A-NH2 did not significantly change or reduce isoprostane levels, lipid hydroperoxides, PON-1 and PAF-AH activity, or IL-6 levels.
Urine samples were collected in sterile tubes for creatinine and isoprostane analysis.
Lipid peroxidation was studied by plasma and urine malondialdehyde and urine isoprostane concentrations (iPF2?
Isoprostane decreased by 27% in both almond groups when compared to the control period, suggesting a possible threshold effect for that biomarker.