isophane insulin

i·so·phane in·su·lin

a modified form of insulin composed of insulin, protamine, and zinc; an intermediately acting preparation used for the treatment of diabetes mellitus.
Synonym(s): NPH insulin
Farlex Partner Medical Dictionary © Farlex 2012

NPH in·su·lin

(in'sŭ-lin)
Modified form of insulin composed of insulin, protamine, and zinc; an intermediately acting preparation used for the treatment of diabetes mellitus.
Synonym(s): isophane insulin.
[Neutral Protamine Hagedorn]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

isophane insulin

A form of insulin modified by adsorption on to a protein molecule protamine so as to act for up to about 12 hours with delayed onset of action. Brand names are Humulin I, Hypurin Bovine Isophane, Hypurin Porcine Isophane and Hypurin Porcine Biphasic Isophane.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

NPH in·su·lin

(in'sŭ-lin)
Modified form of insulin composed of insulin, protamine, and zinc; an intermediate-acting preparation used for the treatment of diabetes mellitus.
Synonym(s): isophane insulin.
[Neutral Protamine Hagedorn]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Berghold et al., "Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus," Cochrane Database of Systematic Reviews, no.
Four patients administered three injections per day: Actraphane before breakfast, soluble insulin (Actrapid) before supper, and isophane insulin (Protaphane) at 21h00, and only one was on a basal-bolus regimen (isophane insulin at 21h00 hours, with soluble insulin boluses before each meal).
Diabetes is covered by soluble insulin, and intermediate-acting insulin (compound insulin zinc suspension or isophane insulin).
Patients were randomized to either glargine (Lantus; Aventis) or human premix insulin (mixture of 30% neutral soluble insulin and 70% isophane insulin) to be administered subcutaneously at bedtime (glargine) or twice a day (human premix insulin), using a pen injector or insulin syringe as preferred by patient for 24 weeks.
Various insulin regimens are available: very rapid acting (lispro and aspart), rapid acting (regular), intermediate acting (isophane insulin [NPH] and lente) and very long acting (ultralente and glargine).
(19) TABLE 2 Insulin formulations Effective Insulin * Onset Peak duration (h) Rapid-acting Lispro 5-15 min 30-90 min 5 Aspart 5-15 min 30-90 min 5 Short-acting Regular U100 30-60 min 2-3 h 5-8 Regular U500 30-60 min 2-3 h 5-8 Intermediate-acting Isophane insulin 2-4 h 4-10 h 10-16 (NPH) Insulin zinc 2-4 h 4-12 h 12-18 Long-acting Insulin zinc 6-10 h 10-16 h 18-24 extended Insulin glargine 2-4 h ([dagger]) No pronounced 20-24 peak Premixed 70% NPH/ 30-60 min Dual 10-16 30% regular 50% NPH/ 30-60 min Dual 10-16 50% regular 75% NPL/ 5-15 min Dual 10-16 25% lispro 70% NP/ 5-15 min Dual 10-16 30% aspart * Assuming 0.1-0.2 U/kg per injection; onset and duration may vary by injection site (except for insulin glargine).