isometheptene


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isometheptene

A SYMPATHOMIMETIC drug used to treat MIGRAINE. A brand name of a preparation with paracetamol is Midrid.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The third product, acetaminophen, dichloralphenazone, and isometheptene (Epidrin, LarkaDrin, Migragesic IDA) is an over-the-counter tablet.
Villalon, "Pharmacological analysis of the mechanisms involved in the tachycardic and vasopressor responses to the antimigraine agent, isometheptene, in pithed rats," Life Sciences, vol.
United States-based Tonix Pharmaceuticals has received approval from the US Food and Drug Administration for its new drug application to assess TNX-201, a single isomer of isometheptene to treat episodic tension-type headache, it was reported today.
At the time of evaluation with the headache clinic, she was on topiramate, magnesium, combination of isometheptene mucate, dichloralphenazone, and acetaminophen and as needed oxycodone, which she used 2-3 tablets per week.
The ingredient isometheptene, found in Midrin, an over-the-counter medication used to treat migraines, was also reported to cause postpartum cerebral angiopathy when it was taken in excess of the recommended amount (Raroque, Tesfa, & Purdy, 1993).
Many other drugs have been used in treating migraines, including: acetaminophen (alone, or in combination with caffeine and butalbital, aspirin and caffeine, or isometheptene and dichloralphenazone); NSAIDs, including aspirin; chlorpromazine (Thorazine); dimenhydrinate (Dramamine); diphenhydramine (Benadryl); morphine; meperidine; intranasal butorphanol (Stadol); and corticosteroids.
Numerous other drugs have been used in treating migraines, including acetaminophen (alone, or in combination with caffeine and butalbital, aspirin and caffeine, or isometheptene and dichloralphenazone); NSAIDs, including aspirin; chlorpromazine (Thorazine); dimenhydrinate (Dramamine); diphenhydramine (Benadryl); morphine; and meperidine.
In 35.8% of these cases, the Remedi library search algorithm found no candidates at all and reported "No Candidates, No Match", whereas in 41.8% of the cases the following library entries were reported as candidates (cited as printed), but a match was not obtained: "Fenfluramine, N-desmet", "Phenylpropanolamine/(Norpseudoephedrine)", "Pseudoephedrine, N-de", "*Prolintane Metab.#2", "Isometheptene Metab.#", "AMPHETAMINE/(Phentermine)/(Phenethylamine)", "Mexiletine".
The United States Headache Consortium has determined that the combination of isometheptene, acetaminophen, and dichlorphenazone (Midrin), though not as effective as the triptans, may be useful in treating mild-to-moderate migraine.
Other migraine drugs include acetaminophen (alone, or in combination with caffeine and butalbital, aspirin and caffeine, or isometheptene and dichloralphenazone): NSAIDs, including aspirin; chlorpromazine (Thorazine); dimenhydrinate (Dramamine); diphenhydramine (Benadryl); morphine; meperidine; intranasal butorphanol (Stadol); and corticosteroids.
* In addition to the triptans, aspirin, ergotamines, and isometheptene should be avoided.