isoenzyme


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to isoenzyme: isoenzyme electrophoresis

isoenzyme

 [i″so-en´zīm]
any of several forms of an enzyme that all catalyze the same reaction but may differ in reaction rate, inhibition by various substances, electrophoretic mobility, or immunologic properties. Several enzymes, particularly alkaline phosphatase, lactate dehydrogenase, and creatine kinase, have clinically important isoenzymes. Isoenzymes are separated by electrophoresis, and the pattern indicates which damaged organ has released the enzymes.

i·so·en·zyme

(ī'sō-en'zīm),
An enzyme (one of a group) that catalyze the same reaction but may be differentiated by variations in physical properties, such as isoelectric point, electrophoretic mobility, kinetic parameters, or modes of regulation, for example, lactate dehydrogenase, a tetramer composed of varying amounts of α and β subunits (that is, 4α, 3α + 1β, 2α + 2β, 1α + 3β, and 4β).
Synonym(s): isozyme

isoenzyme

/iso·en·zyme/ (-en´zīm) isozyme.

isoenzyme

(ī′sō-ĕn′zīm′)
n.
An isoform that is an enzyme.

i′so·en·zy′mic adj.

isoenzyme

[ī′sō·en′zīm]
Etymology: Gk, isos + en, in, syme, ferment
a chemically distinct form of an enzyme. The various forms are distinguishable in analysis of blood samples, which aids in the diagnosis of disease. Different enzymes that catalyze the same physiological reaction may also exist as isoenzymes in different animal species. Also called isozyme.

i·so·en·zyme

(ī'sō-en'zīm)
One of a group of enzymes that catalyze the same reaction but may be differentiated by variations in physical properties, such as isoelectric point, electrophoretic mobility, kinetic parameters, or modes of regulation.

isoenzyme (isozyme)

one of a number of ENZYMES that catalyse the same reaction, but are qualitatively different from each other, for example in PRIMARY STRUCTURE.

Isoenzyme

One of a group of enzymes that catalyze the same reaction but are differentiated by variations in physical properties.

isoenzyme

any of the several forms of an enzyme, all of which catalyze the same reaction, but which may differ in reaction rate, inhibition by various substances, electrophoretic mobility or immunological properties. Several enzymes, particularly alkaline phosphatase, lactate dehydrogenase and creatine kinase, have clinically important isoenzymes. Isoenzymes are separated by electrophoresis, and the pattern indicates which damaged organ has released the enzymes.
References in periodicals archive ?
Malate dehydrogenase (MDH) isoenzyme profiles of hybrid Shaktiman-1, Shaktiman-2 and their parents*.
Immunoenzymometric assay of human glycogen phosphorylase isoenzyme BB in diagnosis of ischemic myocardial injury.
Different garlic preparations have shown diverse and highly variable results of the effects of CYP isoenzymes and metabolism
Electrophoresis was conducted at the same voltage as esterase isoenzyme electrophoresis, and the gel was stained using the method described in the study by Li et al.
The objective of this study was to determine the levels of serum LD2 isoenzyme and b2m in patients of NHL and to correlate these levels in NHL patients with and without bone marrow infiltration.
To date, about 16 CA isoenzymes responsible for various functions have been identified.
CP is a multigene family, which consists of several related enzymes, including isoenzymes involved in four hydroxylations Lu and West (1980).
Adenosine deaminase (ADA) isoenzyme analysis in pleural effusions: diagnostic role, and relevance to the origin of increased ADA in tuberculous pleurisy.
These results are comparable to isoenzymes AcP1 and AcP2 isolated from rat liver [12] and isoenzymes from other sources [23-24].
Chlorphenamine also inhibits isoenzyme CYP 2D6 responsible for the biotransformation of dextromethorphan; when the two drugs are combined together, the patient is likely to experience serotonin syndrome.
The first is attributed to the peripheral conversion of androstenedione to testosterone by other 17-[beta]-HSD isoenzymes particularly isoenzyme five in extragonadal tissues.
Characterization of the major laccase isoenzyme from Trametes pubescens and regulation of its synthesis by metal ions.