isocitrate lyase

i·so·cit·rate ly·ase

an enzyme that catalyzes the reversible aldol condensation of glyoxylate and succinate, forming threo-ds-isocitrate; participates in the glyoxylate cycle.
References in periodicals archive ?
The latter produces glyoxylate and succinate in the reaction catalyzed by isocitrate lyase.
The inhibitory activity of 3-nitropropionamides on isocitrate lyase in M.
Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sufates from the tropical sponge Dysidea sp.
Bromophenols as Candida albicans isocitrate lyase inhibitors.
When this 'switch' is turned on an enzyme called isocitrate lyase (ICL) is expressed, leading to activation of the T3SS.
Compounds that have potential activity versus nonmultiplying bacilli include congeners of metronidazole and isocitrate lyase inhibitors.
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.
The research program includes the pleuromutilins, a novel class of antibiotics, and two target-based projects, isocitrate lyase (Icl) and InhA.
tuberculosis that lack the gene for this enzyme, known as isocitrate lyase, had concentrations of the disease-causing bacteria in their lungs similar to those in mice infected with normal M.
Surprisingly large portions of the genome encode either enzymes of fatty acid metabolism, such as isocitrate lyase, or acidic, glycine-rich polypeptides of unknown function.
McKinney, Jacobs, and their colleagues are taking another tack toward new TB treatments, using the crystal structure of isocitrate lyase as a blueprint.
Bugg says the researchers have harvested plenty of new data from the remaining three: porcine pancreatic elastase (a pig enzyme similar to one that damages lung tissue in leukemia patients); isocitrate lyase (an enzyme in nematodes); and gamma interferon (a protein that stimulates the immune system).