isocitrate dehydrogenase


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i·so·cit·rate de·hy·dro·gen·ase

one of two enzymes that catalyze the conversion of threo-ds-isocitrate, the product of the action of both aconitase and isocitrate lyase, to α-ketoglutarate (2-oxoglutarate) and CO2; one of the isozymes uses NAD+ (participating in the tricarboxylic acid cycle), whereas the other uses NADP+.

i·so·ci·trate de·hy·dro·gen·ase

(ī'sō-sit'rāt dē'hī-droj'ĕn-ās)
One of two enzymes that catalyze the conversion of threo-ds-isocitrate to α-ketoglutarate (2-oxoglutarate) and CO2.

isocitrate dehydrogenase

(ī″sō-cĭt′rāt dē″hī-drŏj′ĕn-ās)
An enzyme that catalyzes the conversion of isocitric acid to α-ketoglutaric acid.

isocitrate dehydrogenase

see isocitrate dehydrogenase.
References in periodicals archive ?
Isocitrate Dehydrogenase (IDH) R132H immunohistochemical staining demonstrates infiltrative pattern of growth.
Isocitrate dehydrogenase (IDH) activity in tributyltin chloride (TBTC)-treated osteosarcoma 143B cybrids.
Effects of Ca and TFP on Nitrate Reductase, Glutamine Synthetase, Glutamate Synthase, Glutamate Dehydrogenase and Isocitrate Dehydrogenase Activity
SOD2 and isocitrate dehydrogenase 2, which regulates the ratio of GSH to GSSG, were reported to be targets of SIRT3 [40]; thus we investigated the effects of these polyphenols on SOD2 activity and GSH/GSSG ratio.
fumarase, fumarate reductase, citrate synthase were not isolated; however, aconitase and isocitrate dehydrogenase were isolated.
High fructose fed rats showed reduced activities of isocitrate dehydrogenase and succinate dehydrogenase enzymes.
Several interesting gene associations fell out of the analysis, including confirmation that the gene associated with neurofibromatosis (NF1) is associated with sporadic glioblastoma, and that mutations in the isocitrate dehydrogenase 1 (IDH1) gene are associated with disease in younger patients and in individuals with secondary tumors.
1995) studied the isozyme systems: isocitrate dehydrogenase (IDH), phosphoglucoisomerase (PGI), phosphoglucomutase (PGM), shikimate dehydrogenase (SKDH), 6-phosphogluconate dehydrogenase (6-PGD), leucine aminopeptidase (LAP) and malate dehydrogenase (MDH) in a total of 36 sweet, sour and ground cherries, verifying that this technique was efficient in detect polymorphism among them.
The tested enzymes were aconitase (ACO), acid phosphatase (ACP), alcohol dehydrogenase (ADH), adenylate kinase (AK), arginine aminopeptidase (AMP), diaphorase (DIA), endopetidase (EP), esterase (EST), fructose-1,6-diphosphatase (FDP), glutamate dehydrogenase (GDH), glutamate oxaloacetate transaminase (GOT), hexokinase (HK), isocitrate dehydrogenase (ICD), leucine aminopeptidase (LAP), malate dehydrogenase (MDH), malic enzyme (ME), peptidase with leucyl-alanine (PEP-LA), 6-phosphogluconate dehydrogenase (PGD), phosphoglucoisomerase (GPI), and shikimate dehydrogenase (SKDH) (Siciliano and Shaw, 1976; Vallejos, 1983; Van Geyt and Smed, 1984; Acquaah, 1992).
2] is reductively fixed in an organic molecule, the enzyme isocitrate dehydrogenase (ICDH) is oxidized; the oxidized enzyme is ultimately reduced back to its original form by the mediator methyl viologen ([MV.
We examined the genotype of each sampled trunk using horizontal starch gel protein electrophoresis, assaying for the following allozymes: acid phosphatase (ACP), alcohol dehydrogenase (ADH), fluorescent esterase (FE), glutamate dehydrogenase (GDH), glutamate oxaloacetate (GOT), isocitrate dehydrogenase (IDH), leucine aminopeptidase (LAP), malate dehydrogenase (MDH), peroxidase (PER), 6-phosphogluconate dehydrogenase (6-PGD), phosphoglucose isomerase (PGI), and phosphoglucomutase (PGM).
Notably, these effects were reversible when treated with an isocitrate dehydrogenase 1 (IDH1) inhibitor discovered, developed and provided by Agios, which blocks the production of 2-HG.