Isocitrate dehydrogenase 1 (IDH1) R132H immunoreactivity in a diffuse astrocytoma.
Isocitrate dehydrogenase mutation is a somatic mutation (and not a germline mutation) in the overwhelming majority of brain tumors.
Caption: Figure 3: Immunohistology of
isocitrate dehydrogenase (IDH2) expression in different renal tumors.
McAlister-Henn, "NAD+-dependent
isocitrate dehydrogenase. Cloning, nucleotide sequence, and disruption of the IDH2 gene from Saccharomyces cerevisiae," Journal of Biological Chemistry, vol.
[5] Nonstandard abbreviations: OMIM, Online Mendelian Inheritance in Man; TCA, tricarboxylic acid; IDH,
isocitrate dehydrogenase; SDH, succinate dehydrogenase; FH, fumarate hydratase; PHD, prolyl hydroxylase domain protein; HIF, hypoxia-inducible factor; NRF2, nuclear factor (erythroid-derived 2)-like 2; NQO1, NAD(P)H:quinone oxidoreductase 1.
Tipton, "The activation of ox-brain NAD+-dependent
isocitrate dehydrogenase by magnesium ions," European Journal of Biochemistry, vol.
The IDH1 and IDH2 genes encode two critical metabolic enzymes:
isocitrate dehydrogenase 1 (present in the peroxisomes and cytosol) and
isocitrate dehydrogenase 2 (present in the mitochondria).
NAD-dependent
isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells.
Keywords: Calmodulin; Glutamate synthase; Glutamate dehydrogenase,
Isocitrate dehydrogenase; Respiration rate
The gene,
isocitrate dehydrogenase, or IDH, had long been considered humdrum, a so-called housekeeping gene that directs cells to make an enzyme used in energy production.
(2,3,5,6) Additionally, Pansuriya and coworkers recently found that there are also mutations in the gene encoding
isocitrate dehydrogenase 1 and 2 in enchondromas and spindle cell hemangiomas.
The third pathway is pyruvate-isocitrate pathway involving cytosolic
isocitrate dehydrogenase that uses NADP as its cofactor [47].
