isochromosome


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isochromosome

 [i″so-kro´mo-sōm]
an abnormal chromosome having a median centromere and two identical arms, formed by transverse, rather than normal longitudinal, splitting of a replicating chromosome.

i·so·chro·mo·some

(ī'sō-krō'mō-sōm),
A chromosomal aberration that arises as a result of transverse rather than longitudinal division of the centromere during meiosis; two daughter chromosomes are formed, each lacking one chromosome arm but with the other doubled.

i·so·chro·mo·some

(ī'sō-krō'mŏ-sōm)
A chromosomal aberration that arises as a result of transverse rather than longitudinal division of the centromere during meiosis; two daughter chromosomes are formed, each lacking one chromosome arm but with the other doubled.

isochromosome

An abnormal chromosome formed when, during the ANAPHASE of cell division, the CENTROMERE divides horizontally rather than longitudinally, thus producing a chromosome with two long arms and one with two short arms.
References in periodicals archive ?
An abnormal clone (20% metaphase cells) showed the presence of an anomalous extra isochromosome 12p, the short arm of chromosome 12, indicating tetrasomy 12p.
Recurrent abortion associated with a balanced 22;22 translocation, or isochromosome 22q in a monozygous twin.
The isochromosome 46,X,i(X)(q10) is a duplication of the long arm of the X chromosome, fused at the head with a missing short arm [4].
Structural and functional evidence that a B chromosome in the characid fish Astyanax scabripinnis is an isochromosome. Heredity, vol.
Females with an isochromosome of the long arms of the X chromosome have larger and more frequent drumsticks, whereas females with deletions from the X chromosome have smaller drumsticks (1), (15).
Siepman et al., "Isochromosome (12p) and peritriploidy in a highly malignant extrarenal rhabdoid tumor," Cancer Genetics and Cytogenetics, vol.
double Ph, isochromosome 17q, trisomy 8 FISH analysis optional: * Only done where conventional cytogenetics not available or fails * Or, to document a BCR-ABL positivity for variant translocation and masked Ph Note: If BM material unavailable (e.g.
This was the irst report of what White correctly interpreted as a B isochromosome, a type of supernumerary later found in other grasshopper species (Hewitt 1973; Camacho et al.
A high incidence of isochromosome 12p in leukaemic blasts has been reported and this is a genetic abnormality found in EGCT and gonadal GCT [23].
In addition, seven of the 20 cells contained an additional isochromosome 8q resulting in an 8q tetrasomy.
(5) Tetrasomy 18p is a chromosome abnormality in which, in addition to the normal 23 pairs of chromosomes, an individual has an additional chromosome, called an isochromosome, composed of two copies of the short arm of chromosome 18.