isochromosome


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isochromosome

 [i″so-kro´mo-sōm]
an abnormal chromosome having a median centromere and two identical arms, formed by transverse, rather than normal longitudinal, splitting of a replicating chromosome.

i·so·chro·mo·some

(ī'sō-krō'mō-sōm),
A chromosomal aberration that arises as a result of transverse rather than longitudinal division of the centromere during meiosis; two daughter chromosomes are formed, each lacking one chromosome arm but with the other doubled.

isochromosome

/iso·chro·mo·some/ (-kro´mah-sōm) an abnormal chromosome having a median centromere and two identical arms, formed by transverse, rather than normal longitudinal, splitting of a replicating chromosome.

isochromosome

[-krō′məsōm]
a chromosome whose arms are of equal length.

i·so·chro·mo·some

(ī'sō-krō'mŏ-sōm)
A chromosomal aberration that arises as a result of transverse rather than longitudinal division of the centromere during meiosis; two daughter chromosomes are formed, each lacking one chromosome arm but with the other doubled.

isochromosome

An abnormal chromosome formed when, during the ANAPHASE of cell division, the CENTROMERE divides horizontally rather than longitudinally, thus producing a chromosome with two long arms and one with two short arms.

isochromosome

an abnormal chromosome having a median centromere and two identical arms, formed by transverse, rather than normal longitudinal, splitting of a replicating chromosome.
References in periodicals archive ?
It confirmed the assumption of origin of the 14 M constitution while at the same time implying that isochromosomes can be stable members of normal complements when genetic regulation excludes internal pairing.
Cytogenetic analysis is also critical for the detection of additional abnormalities that are commonly present at disease progression, such as trisomy 8 (+8) or isochromosome 17q (i(17q)), among others.
Although viruses do not seem to transform the T cells directly by integration into their DNA, the chronic antigen stimulation from viral infection may drive the proliferation of polyclonal [gamma]/[delta] T-cells, (7,8) setting the stage for cytogenetic and molecular anomalies, such as isochromosome arm 7q, and eventually transforms a T-cell clone.
4,5) Consequently, MTGCTs exhibit genetic markers, such as a 12p isochromosome and chromosome 12 overrepresentation, (6) that are less frequently observed in MOGCTs, (7) which often resemble testicular infantile teratomas/yolk sac tumours, (8) with the pure ovarian teratomas showing negativity for 12p.
All cases were also negative for isochromosome 17q by fluorescent in situ hybridization.
Isochromosome 12p by cytogenetic studies can be confirmatory in difficult cases.
Cytogenetics of twelve cases of uveal melanoma and patterns of nonrandom anomalies and isochromosome formation.
Although most adult, malignant GCTs have the isochromosome 12p abnormality, this aberration is very rare in children younger than 10 years.
15) An isochromosome 1q has been reported in a subset of recurrent chordomas, (6) and familial kindreds of clival chordomas often feature deletion of 1p36 as a key molecular defect.
TCRG gene rearrangements +/-, variable TCRB gene rearrangements 2/+; isochromosome 7q and trisomy 8 common.
Classic seminomas, in contrast, reveal a consistent structural chromosomal abnormality of isochromosome 12p.
4,10,12,20,24) In our series, some of the oncocytomas showed a complex karyotype (chromosome 21 loss and an isochromosome 9p with 9q loss).