Isocarboxazid was started at 20 mg/day and increased as needed and tolerated to a maximum of 60 mg/day.
"In this trial, isocarboxazid showed very robust clinical efficacy in the prophylactic treatment of migraine attack," Dr.
Tyramine-containing foods plus furazolidone, isocarboxazid
, phenelzine, selegiline, or tranylcypromine: May cause dangerously high blood pressure.
and phenelzine are the 2 hydrazine MAOIs available in the United States, while tranylcypromine and selegiline transdermal are nonhydrazines (Figure 2).
(2) Lastly, because VMAT2 inhibition may alter synaptic levels of other monoamines, it is recommended that valbenazine not be administered with monoamine oxidase inhibitors, such as isocarboxazid
, phenelzine, or selegiline.
(Marplan) phenelzine (Nardil) selegiline (Carbex, Eldepryl) tranylcypromine (Pamate) Other Medications bisacodyl (Dulcolax) Stimulant laxative.
(11) The manic switch has occurred, however, after use of isocarboxazid, (8) trazodone, (12) and, in this case, phenelzine, which have only mild anticholinergic activity.
Rothschild AJ: Mania after withdrawal of isocarboxazid. J Clin Psychopharmacol 1985; 5:340-342
The package inserts of the MAOIs isocarboxazid
, phenelzine, selegiline, and tranylcypromine provide limited data and dosage recommendations for use in the context of renal impairment.
Four MAOIs are available in the United States: tranylcypromine, phenelzine, isocarboxazid
, and selegiline.
John's wort), imipramine, MDMA, meperidine, nefazodone, nortriptyline, paroxetine, protriptyline, sertraline, tramadol, trazodone, venlafaxine Drugs that decrease Isocarboxazid
, linezolid, phenelzine, 5-HT metabolism selegiline, tranylcypromine Drugs that are direct Almotriptan, buspirone, dihydroergotamine, 5-HT agonists eletriptan, frovatriptan, LSD, naratriptan, rizatriptan, sumatriptan, zolmitriptan Others L-tryptophan, carbamazepine, carisoprodol, droperidol, levodopa, lithium, metoclopramide, pentazocine, phenylpropanolamine 5-HT: serotonin; LSD: lysergic acid; MDMA: methylenedioxymethamphetamine Source: Reference 1 A combination of PK and PD interactions also may increase the risk of serotonin syndrome.