islet transplantation

islet transplantation

An alternative to pancreatic transplantation in patients whose conventional diabetic control is threateningly poor and whose risk of diabetic complications and shortening of life is considered high. A lesser degree of immunosuppression is required than panceras transplantation and the surgery is minor. Purified ISLETS OF LANGERHANS are digested from a donor pancreas and are infused through a catheter passed through the liver into the portal vein from whence the islets pass into the sinusoids of the liver. The method is still considered experimental.
References in periodicals archive ?
In addition, in islet transplantation helpful in monitoring microbial contamination rates of islet cell product.
Type 1 diabetes mellitus can be alleviated through islet transplantation (ITx).
Objective: To evaluate the effects on filtration membrane of glomerulus after islet transplantation in a rat model of streptozotocin-induced diabetic nephropathy.
The standard of care for islet transplantation is limited to diabetic patients with severe hypoglycemia unawareness due to both a lack of cadaveric donor islets and a requirement for life-long use of toxic anti-rejection drugs.
Islet Sciences added that Dr Jonathan Lakeym has stepped down as the company's director and chief scientific officer to dedicate more time to islet transplantation research.
Long-term immunosuppression after islet transplantation has also resulted in a significant percentage of premenopausal females (70%) developing sirolimus-associated ovarian cysts with a mean ovarian cyst size of 6 cm.
The expertise gathered include encapsulation techniques, islet isolation, cell engineering, islet transplantation, islet preconditioning, surgical implantation, and medium formulation; items that are complementary and necessary to the implementation of the present project proposal.
Entitled "A Phase I/II Study of the Safety and Efficacy of Sernova's Cell Pouch for Therapeutic Islet Transplantation," the study will be conducted in collaboration with Dr James Shapiro at the University of Alberta Health Science Centre in Edmonton.
This assay provides the type 1 diabetes, and more specifically the islet transplantation, research field a long awaited high quality tool for measuring the islet-specific biomarker.
Islet transplantation into the portal vein is the current clinical practice.
Inconsistent islet isolation is one of the important issues in clinical islet transplantation," said Dr.
Weir, head, section of Islet transplantation and cell biology at the Joslin Diabetes Center in Boston, US, said.