islet cell antibody


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islet cell antibody (ICA)

[ī′lit]
Etymology: MFr, islette, little island
an immunoglobulin that reacts with cytoplasmic components of all of the cells in the pancreatic islets. These antibodies occur in about 60% to 70% of newly diagnosed patients with insulin-dependent diabetes mellitus, providing strong evidence for an autoimmune origin and pathogenesis of the disease. The presence of ICA can be demonstrated for years before the occurrence of symptoms. The antibody tends to disappear with time.
References in periodicals archive ?
Assessment of precision, concordance, specificity, and sensitivity of islet cell antibody measurement in 41 assays.
Combined analysis and single step detection of GAD65 and IA2 autoantibodies in IDDM can replace the histochemical islet cell antibody test.