The transplant procedure includes selecting donors who meet the standard screening and testing performed on all nonliving donors as well as the criteria specific to the protocol, which includes that the islet cells
meet predefined standards for purity and viability.
Q: What has been the overall patient response to the islet cell
Our studies demonstrated marked levels of [p27.sup.kip1] protein in the nucleus and cytosol of both insulinomas and normal islet cells
. Cytoplasmic expression of [p27.sup.kip1] protein was the predominant localization and was similar in both cases.
Although a biopsy with histology of the islet cells
could provide insight into the detailed mechanism for the functional improvement of the [beta]-islet cells, this procedure carries too many risks for a nonterminal condition such as diabetes mellitus.
It can be prepared as a cell scaffold to support and protect cells and can be used to provide a three-dimensional (3D) environment for in vitro cell cultures.[sup] Studies have shown that islets have significantly better survival and functionality when cultured in a PGA scaffold, compared with traditional culture.[sup] If EC-coated islets are cultured in the PGA scaffold, the 3D culture environment would shorten the distance between islets and ECs, providing better support for ECs to attach to the islet cells
during the early culture period.
It is possible that other food proteins play a role in pancreatic cell cross-reactivity leading to islet cell
Conclusion: The relatives of both types of diabetic patients showed immunity to islet cell
autoantibodies which confirmed the effect of genetic factors in disease pathogenesis and may be important in disease prediction.
The ICMC team brought together cutting-edge skills and techniques for islet cell
preparation and gene expression characterisation.
A better diabetes treatment, many researchers believe, would be to replace patients' destroyed pancreatic islet cells
with healthy cells that could take over glucose monitoring and insulin release.
The trouble is, those who receive an islet cell
transplant must take immunosuppressant drugs for the rest of their life, which can be very taxing on the body.
Cherie Stabler, an associate professor of biomedical engineering at the University of Florida, says this approach is impressive because it tackles all aspects of the problem of islet cell
delivery, including finding a source of cells, preventing an immune response, and developing a suitable delivery material.
123 EMERGING NEW DIABETES TREATMENT STRATEGIES: BETATROPHIN VERSUS ISLET CELL