Hallenbeck's laboratory is studying the cellular regulation of ischemic tolerance
and inflammatory and immune mechanisms in the initiation and progression of stroke.
NO deficiency and endothelial dysfunction due to the existence of multiple potential anti-angiogenic factors such as increased plasma ADMA level in patients with CKD has been found to impair the microvascular adaptation and ischemic tolerance
of tissues (2).
In our laboratory, we have recently shown that pretreatment with various dietary doses of virgin olive oil induces ischemic tolerance and confers different degrees of neuroprotection in the rat brain (Mohagheghi et al.
2008), the focal cerebral ischemia rat model was used for proof-of-concept for ischemic tolerance because it is well established for illustrating neuroprotection.
Normobaric hyperoxia induces ischemic tolerance and upregulation of glutamate transporters in the rat brain and serum TNF-[alpha] level.
Some topics covered include longitudinal optical imaging for locomotor recovery after stroke, neuroimaging of depressive disorders associated with cerebrovascular disease, differences in imaging arterial infarction and venous infarction of the brain, and imaging of ischemic tolerance
in the brain.
Scientists from many parts of the world report and review recent research findings on such aspects as whether age influences ischemic tolerance
in the brain, perfusion imaging in acute ischemic stroke, neuro-regeneration in the immature brain, and perinatal hypoxic brain injury.
The proteomic and genomic responses to ischemia and particularly the phenomenon of ischemic tolerance
and its neuroprotective mechanisms in the brain, are areas of concentrated interest.