Characterization of these cells in an ischemia/reperfusion test system thus would be important, since little is known about the ischemic tolerance of hESC-derived cardiomyocytes.
To investigate if endogenous NO affects ischemic tolerance of differentiated EBs derived from hESCs, a nonspecific NOS inhibitor, L-NNA, was given during SI.
Hallenbeck's laboratory is studying the cellular regulation of ischemic tolerance
and inflammatory and immune mechanisms in the initiation and progression of stroke.
This functional-protectoral role of the proto-oncogenes depends on the degree of created ischemic tolerance.
Bilateral ischemic tolerance of rat hippocampus induced by prior transient focal ischemia: relation to c-Fos mRNA expression.
NO deficiency and endothelial dysfunction due to the existence of multiple potential anti-angiogenic factors such as increased plasma ADMA level in patients with CKD has been found to impair the microvascular adaptation and ischemic tolerance
of tissues (2).
In our laboratory, we have recently shown that pretreatment with various dietary doses of virgin olive oil induces ischemic tolerance and confers different degrees of neuroprotection in the rat brain (Mohagheghi et al.
2008), the focal cerebral ischemia rat model was used for proof-of-concept for ischemic tolerance because it is well established for illustrating neuroprotection.
High degree of brain ischemic tolerance was noted in 536 cases, satisfactory degree--in 127, and critical degree--in 11 cases.
For protection of a brain we used a method of an artificial hypertension, deepening of narcosis and pharmacological protection, with application of antihypoxants and stabilizers of cellular membranes, irrespective to initial degree of brain ischemic tolerance.
Some topics covered include longitudinal optical imaging for locomotor recovery after stroke, neuroimaging of depressive disorders associated with cerebrovascular disease, differences in imaging arterial infarction and venous infarction of the brain, and imaging of ischemic tolerance
in the brain.
Scientists from many parts of the world report and review recent research findings on such aspects as whether age influences ischemic tolerance
in the brain, perfusion imaging in acute ischemic stroke, neuro-regeneration in the immature brain, and perinatal hypoxic brain injury.