Comparison of the stress tests performed at the 6th month showed that the
ischemic threshold of 1 mm was significantly delayed by 2 min 41 s in the trimetazidine group (P < 0.001) versus 42 s in the placebo group (NS).
Clinical studies have shown that these agents can substantially increase the
ischemic threshold in patients with effort angina.
This incomplete relaxation of the bridge during diastole results in increased intracoronary flow velocities, reduced diastolic coronary flow, retrograde coronary flow, and a reduction in coronary flow reserve, resulting in a lowered
ischemic threshold (6).
Research: Italian scientists at the University of Ancona Hospital conducted a study that investigated biological endpoints such as functional capacity and
ischemic threshold, in a randomized, placebo-controlled, crossover clinical trial.
Chelation therapy, promoted as a complementary or alternative treatment for ischemic heart disease, does not increase the
ischemic threshold or improve quality of life, according to Dr.
These studies focused on determining the
ischemic threshold, as well as comparing readings to ICP and CPP.[12,25,40] One study measured mean brain p[O.sub.2] after occlusion of the middle cerebral artery, documenting a decrease to 19 mm Hg following occlusion.[40] The ischemic endpoint in another study was determined to be the presence of an induced infarct.[12] This occurred at a p[O.sub.2] of 20 mm Hg.
