In completed studies to date, PLX-PAD demonstrated significant improvement in reducing the risk for amputation and death, improved tissue perfusion and reduced ischemic pain
, all while demonstrating a very favorable safety profile.
* Mixed neuropathic pain, phantom limb pain, postherpetic neuralgia, fibromyalgia, cancer pain, ischemic pain
, migraine headache, and lowback pain: weak to no evidence.
Herein, we report a case with persistent ischemic pain
and necrotic wounds successfully treated with SCS implantation for inoperable peripheral vascular disease (PVD).
Patients with diabetic foot ulcers have coexisting PAD at a proportion of approximately 50% and may suffer from chronic ischemic pain
Eligible patients were men and women 18 to 65 years of age with atherosclerotic Ischemic Peripheral Arterial Disease (PAD) or Thromboangiitis Obliterans (TAO)/Buerger's disease of the lower extremities defined as ischemic pain
at rest and minor tissue loss and ischemic ulcers or gangrene, which may be dry or humid, with Ankle Brachial Index (ABI) [less than or equal to] 0.6 or ankle pressure [less than or equal to] 60 mmHg or TcP[O.sub.2] [less than or equal to] 35 mmHg in the foot, without acceptable options for revascularization.
Data from the two Phase 1 studies showed a favorable safety profile and promising data on amputation free survival one year after treatment, improved tissue perfusion, and a reduction of ischemic pain
More importantly, the physicians should have recognized the typical story of myocardial ischemic pain
and managed the patient as someone with an acute coronary syndrome despite his young age and a near-normal ECG.
(5) Likely complications include ischemia and ischemic pain
after embolization, and recanalization of vessels.
Disease states that have been shown to be responsive to stimulation include failed back surgery syndrome, spinal radiculopathy, ischemic pain
, peripheral neuropathy, post herpetic neuritis, traumatic nerve injury, and complex regional pain syndrome.
Burger's disease is a peripheral vascular disorder characterized by constricted blood flow, ischemic pain
, and necrotizing tissue processes.
We should also keep in mind that when we talk about pain from UFE, we're talking about ischemic pain
. It would be interesting to look at ischemic pain
in other scenarios and extrapolate that information to UFE.